Recombinant Zebrafish ADRB3A

• Cat.No.: ADRB3A-6848Z
• Product Overview: Recombinant Zebrafish ADRB3A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: adrb3a adrenoceptor beta 3a [ Danio rerio (zebrafish) ]
• Official Symbol: ADRB3A
• Gene ID: 558248
• mRNA Refseq: NM_001128335
• Protein Refseq: NP_001121807
• UniProt ID: B0UYT9

Reviews

08/19/2022

The technical support provided by the manufacturer is also exceptional.

04/12/2021

The protein is free of any impurities, which often cause unwanted variability in results, and the stability ensures that the protein remains active throughout the duration of my experiments.

12/06/2020

the purity and stability of the ADRB3A protein provided by the manufacturer are critical factors that contribute to the success of my experiments.

03/27/2019

I am confident that utilizing the ADRB3A protein and the manufacturer's technical support will yield significant advancements in the field of metabolic research and contribute to the development of new and effective treatments for metabolic disorders.

Q&As

How do ADRB3A proteins affect lipolysis?

ADRB3A receptors are primarily located in adipose tissue, where they play a role in promoting lipolysis (the breakdown of stored fat). When these receptors are activated, they stimulate the release of fatty acids from adipose tissue, which can be used by the body for energy.

Are there any known side effects of ADRB3A-targeted therapies?

ADRB3A-targeted therapies can have side effects, such as nausea, vomiting, diarrhea, and urinary tract issues. They can also increase heart rate and blood pressure, potentially leading to cardiovascular complications. Additionally, long-term use of these therapies can lead to a decrease in the number of receptors, leading to decreased efficacy and potential tolerance.

How are ADRB3A proteins targeted in medical treatments?

ADRB3A proteins can be targeted in medical treatments through the use of medications known as beta-3 adrenergic receptor agonists or antagonists. Agonists can activate ADRB3A proteins to increase fat burning and energy expenditure, while antagonists can block the activity of these proteins to reduce glucose uptake and insulin secretion.

Are there any side effects associated with ADRB3A-targeted therapies?

ADRB3A-targeted therapies are generally considered safe, but some potential side effects may include increased heart rate, blood pressure, and metabolic rate. These effects may be more pronounced in individuals with cardiovascular disease or other underlying health conditions.

How are ADRB3A proteins related to exercise?

ADRB3A proteins have been implicated in the metabolic response to exercise, particularly with regard to the increase in fat burning and energy expenditure that occurs during physical activity. Some studies suggest that exercise training can increase the expression of ADRB3A in muscle tissue, leading to improved metabolic function and insulin sensitivity.

What are some challenges associated with developing ADRB3A-targeted therapies?

Some of the challenges associated with developing ADRB3A-targeted therapies include achieving selectivity and specificity, determining the optimal dose and treatment duration, and ensuring long-term safety and efficacy in diverse patient populations.

Can ADRB3A proteins be used in cancer treatment?

ADRB3A proteins have been studied for their potential role in cancer development and treatment, as they have been found to be expressed in various types of cancer cells. However, the role of ADRB3A in cancer is complex, and there is not enough evidence to support the use of ADRB3A-targeted therapies for cancer treatment at this time.

How do ADRB3A proteins affect glucose metabolism?

ADRB3A receptors are involved in regulating glucose metabolism, particularly in adipose tissue and skeletal muscle. When activated, ADRB3A receptors promote glucose uptake and utilization in these tissues, potentially leading to improved glucose tolerance and insulin sensitivity.

Can ADRB3A proteins be used to treat type 2 diabetes?

Activation of ADRB3A proteins in pancreatic beta cells can stimulate insulin secretion and improve glucose metabolism, suggesting their potential use in treating type 2 diabetes. However, further research is needed to determine the safety and effectiveness of targeting ADRB3A proteins in diabetes management.

Are there any genetic variations in ADRB3A that affect disease risk?

Yes, several genetic variations (polymorphisms) in the ADRB3A gene have been associated with increased risk of obesity, diabetes, and cardiovascular disease. These variations may affect the function and expression of ADRB3A, leading to altered metabolic and physiological responses.

Can ADRB3A proteins be used to treat type 2 diabetes?

ADRB3A-targeted therapies have been explored as a potential treatment for type 2 diabetes, as they may improve insulin sensitivity and glucose metabolism. However, there are currently no approved drugs that specifically target ADRB3A for the treatment of diabetes.

What medical conditions are ADRB3A proteins associated with?

ADRB3A proteins have been associated with various medical conditions, including obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Polymorphisms in the ADRB3 gene have also been linked to an increased risk of these conditions.

Can ADRB3A proteins be used for weight loss?

The activation of ADRB3A proteins has been studied for its potential effect on weight loss and obesity management. However, results have been mixed, and the long-term safety and efficacy of using ADRB3A agonists for weight loss are still uncertain.

Can ADRB3A proteins be used to treat asthma?

ADRB3A proteins are not commonly used in the treatment of asthma, as they primarily play a role in metabolism and energy expenditure rather than airway constriction. The primary target of asthma treatment is the bronchial smooth muscle, which is targeted by medications such as bronchodilators.