Recombinant Zebrafish AGAP2

• Cat.No.: AGAP2-4968Z
• Product Overview: Recombinant Zebrafish AGAP2 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [ Danio rerio (zebrafish) ]
• Official Symbol: AGAP2
• Gene ID: 565109
• mRNA Refseq: NM_001080018
• Protein Refseq: NP_001073487
• UniProt ID: A0JMI1

Reviews

02/20/2022

Protein’s reliable behavior ensured consistent downstream analyses.

07/13/2020

It's quality ensured reliable downstream analysis without interference. 

02/18/2019

 Compatibility across a range of assays expanded our research potential significantly.

02/15/2019

The experimental group treated with Protein AGAP2 exhibited accelerated wound healing.

02/01/2016

 Replicating outcomes across diverse cell lines emphasized the product’s consistent behavior.

Q&As

How is agap2's expression regulated in different cell types?

Agap2 expression can vary among different cell types and is often regulated by a combination of transcription factors and signaling pathways.

Can agap2 influence cell signaling pathways?

Agap2's involvement in endocytosis can indirectly affect cell signaling by influencing the internalization and processing of cell surface receptors.

Is agap2's function conserved across different species?

Agap2's function in endocytosis is relatively conserved across various species, reflecting its fundamental role in cellular processes.

How do researchers study the role of agap2 in cells?

Researchers often use techniques such as molecular biology, cell imaging, and genetic manipulations to investigate agap2's function, localization, and interactions within cells.

Are there any diseases associated with agap2 dysfunction?

Disruptions in agap2 function have been implicated in certain neurological disorders, potentially affecting cellular communication and signaling.

How does agap2 contribute to endocytosis?

Agap2 interacts with other proteins to promote the assembly of clathrin-coated pits on the cell membrane, facilitating the invagination and internalization of specific molecules.

Are there any genetic mutations associated with agap2?

Genetic variations in the AGAP2 gene have been linked to certain neurological conditions, suggesting its potential involvement in brain function.

What research is ongoing regarding agap2 protein?

Ongoing research aims to uncover the precise mechanisms of agap2's involvement in endocytosis and its potential implications in various diseases, including neurological disorders.

How is agap2 regulated within cells?

Agap2 activity can be regulated by cellular signaling pathways and post-translational modifications, affecting its role in endocytic processes.

Where is agap2 protein found?

Agap2 is present in various cells and tissues throughout the body, contributing to the cellular uptake of nutrients and signaling molecules.

Are there any structural domains within agap2 that are particularly important?

Agap2 contains ANK repeat and PH domains, which are crucial for protein-protein interactions and membrane binding, respectively.

Does agap2 have any interactions with other cellular components?

Agap2 interacts with various proteins involved in endocytosis, including clathrin and other adaptors, to orchestrate the formation of coated vesicles.

What is the full name of the "agap2" protein?

The full name of the protein is "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2."

Can agap2 be localized to specific cellular compartments?

Agap2 can be found in multiple cellular compartments, including the cell membrane and endosomal structures, due to its role in endocytosis.

Can agap2 protein be targeted for therapeutic interventions?

The role of agap2 in endocytosis suggests it could be a potential target for drugs aimed at modulating cellular uptake processes.

What other cellular processes might agap2 be involved in?

Agap2's ANK repeat and PH domains suggest possible roles in protein-protein interactions and membrane binding, respectively, beyond its role in endocytosis.

How does agap2 contribute to the formation of clathrin-coated vesicles?

Agap2 helps regulate the activity of ADP-ribosylation factor (ARF) GTPases, which are critical for initiating the assembly of clathrin-coated vesicles during endocytosis.

What is the function of agap2 protein?

Agap2 helps regulate endocytosis by participating in the formation of clathrin-coated vesicles that transport molecules within cells.

Is agap2 essential for cell survival?

While agap2 is not essential for basic cellular survival, it plays a significant role in maintaining cellular homeostasis and proper functioning.

What is agap2 protein?

Agap2 is a protein that plays a role in endocytosis, which is the process by which cells take in molecules from the external environment.