Recombinant Zebrafish AHSA1L

• Cat.No.: AHSA1L-11881Z
• Product Overview: Recombinant Zebrafish AHSA1L full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ahsa1l AHA1, activator of heat shock protein ATPase homolog 1, like [ Danio rerio (zebrafish) ]
• Official Symbol: AHSA1L
• Gene ID: 321945
• mRNA Refseq: NM_212602
• Protein Refseq: NP_997767
• UniProt ID: Q7SXN3

Reviews

07/30/2022

Product quality exceeded the cost. Customer service was attentive.

09/14/2021

Competitive pricing, premium quality, and friendly customer assistance.

08/07/2020

Value for money with outstanding customer support.

01/19/2019

Affordable pricing, exceptional product quality, and attentive service.

11/01/2018

A perfect balance of quality and price. Customer service was fantastic.

Q&As

Can you outline the steps involved in a co-immunoprecipitation assay to study AHSA1L-Hsp90 interactions?

Steps include cell lysis, immunoprecipitation of AHSA1L or Hsp90, protein separation, and subsequent analysis using immunoblotting or mass spectrometry.

How could insights from AHSA1L research contribute to the development of personalized medicine strategies?

Understanding AHSA1L's role in protein folding could lead to tailored therapeutic interventions based on individual protein folding profiles, benefiting personalized medicine approaches.

How can AHSA1L's interactions be studied using fluorescence-based techniques?

Fluorescence resonance energy transfer (FRET) and fluorescence anisotropy assays can reveal dynamic interactions between AHSA1L and Hsp90.

Elaborate on the structural domains of AHSA1L and their roles in mediating interactions with Hsp90?

AHSA1L contains a TPR (tetratricopeptide repeat) domain that interacts with the C-terminal domain of Hsp90, allowing for co-chaperone complex formation.

What are the implications of AHSA1L's involvement in protein folding for cellular homeostasis?

AHSA1L contributes to maintaining proper protein folding, preventing misfolding and aggregation, which is crucial for cellular function and health.

Discuss the potential implications of AHSA1L's role in the development of drug resistance in cancer cells.

AHSA1L's involvement in stabilizing oncogenic client proteins could contribute to the development of drug resistance in cancer cells.

How might AHSA1L's interactions with co-chaperones contribute to the formation of Hsp90 multi-protein complexes?

AHSA1L interactions with co-chaperones such as p23 and Hop contribute to the assembly of multi-protein complexes that aid in protein folding.

Discuss AHSA1L's role in modulating the activity of steroid hormone receptors and other client proteins?

AHSA1L enhances Hsp90-mediated folding and stabilization of steroid hormone receptors and other client proteins critical for various cellular processes.

How does AHSA1L contribute to the allosteric regulation of Hsp90's ATPase activity?

AHSA1L binding induces structural changes in Hsp90, enhancing its ATPase activity, which is crucial for the chaperone's conformational cycle.

Explain the process of generating AHSA1L knockout cell lines for investigating its functions?

CRISPR/Cas9-mediated genome editing can be employed to generate AHSA1L knockout cell lines, allowing researchers to study its effects on protein folding pathways.