Recombinant Zebrafish AMFR
Cat.No. : | AMFR-12379Z |
Product Overview : | Recombinant Zebrafish AMFR full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | amfr autocrine motility factor receptor, E3 ubiquitin protein ligase a [ Danio rerio (zebrafish) ] |
Official Symbol : | AMFR |
Gene ID : | 406442 |
mRNA Refseq : | NM_213163 |
Protein Refseq : | NP_998328 |
UniProt ID : | Q6PFU8 |
Products Types
◆ Recombinant Protein | ||
Amfr-515M | Recombinant Mouse Amfr Protein, His-tagged | +Inquiry |
AMFR-514H | Recombinant Human AMFR Protein, His-tagged | +Inquiry |
AMFR-3763H | Recombinant Human AMFR protein, His-tagged | +Inquiry |
AMFR-520H | Recombinant Human AMFR protein, GST-tagged | +Inquiry |
AMFR-3783H | Recombinant Human AMFR, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMFR plays a crucial role in protein turnover and degradation pathways, promoting the degradation of misfolded or unwanted proteins through the ubiquitin-proteasome system and autophagy.
AMFR interacts with various cellular proteins involved in protein quality control, including chaperones, ubiquitin ligases, and components of the ERAD machinery.
Depletion or overexpression of AMFR can disrupt cellular proteostasis, leading to the accumulation of misfolded proteins and impaired cell viability.
AMFR is responsible for recognizing and delivering misfolded or aggregated proteins for degradation, thereby preventing their accumulation and proteotoxicity.
AMFR activity and stability can be regulated by post-translational modifications, such as ubiquitination or phosphorylation, and by signaling pathways, including the unfolded protein response (UPR) pathway.
AMFR participates in the endoplasmic reticulum-associated degradation (ERAD) pathway, which targets misfolded proteins in the ER for proteasomal degradation.
AMFR protein is predominantly localized to the endoplasmic reticulum (ER), with a distribution pattern that includes ER membranes and ER-associated structures.
AMFR expression can be upregulated in response to cellular stress, such as oxidative stress or endoplasmic reticulum (ER) stress.
Targeting AMFR holds therapeutic potential for protein aggregation diseases and neurodegenerative disorders by promoting protein clearance and reducing protein aggregates' toxicity.
AMFR may have a role in coordinating cellular responses to DNA damage or genotoxic stress, potentially through its involvement in protein quality control mechanisms.
Customer Reviews (3)
Write a reviewAccurate measurement of protein turnover rates.
Reduced non-specific binding in antibody-based assays.
Compatibility with high-resolution imaging techniques for detailed analysis.
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