Recombinant Zebrafish AND2

• Cat.No.: AND2-6245Z
• Product Overview: Recombinant Zebrafish AND2 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: and2 actinodin2 [ Danio rerio (zebrafish) ]
• Official Symbol: AND2
• Gene ID: 566702
• mRNA Refseq: NM_001111190
• Protein Refseq: NP_001104660
• UniProt ID: A9JRX1

Reviews

10/10/2021

the manufacturer's commitment to delivering the AND2 protein in a timely manner is greatly appreciated.

12/18/2020

The ability to customize the AND2 protein variants or modifications offered by the manufacturer is also advantageous, as it allows me to tailor the protein to my specific research objectives.

07/31/2019

the excellent technical support provided by the manufacturer is of immense value to me.

06/07/2018

The cost-effectiveness of the AND2 protein, competitive pricing, and the availability of bulk purchase options provided by the manufacturer also align with my budget considerations, allowing me to optimize my resources.

11/07/2016

I appreciate the manufacturer's commitment to maintaining exceptional protein quality standards, which ensures reliable and consistent results in my trials.

Q&As

Are there any animal models available to study the function of the AND2 protein?

Yes, several animal models, such as mice and zebrafish, have been used to study the function of the AND2 protein in cardiac development and disease. These models allow researchers to better understand the consequences of AND2 gene mutations and investigate potential therapeutic interventions.

What other cellular processes or pathways are regulated by the AND2 protein?

In addition to its role in maintaining sarcomere structure, the AND2 protein can also regulate other cellular processes. For example, it has been shown to interact with signaling molecules involved in cell adhesion, migration, and cytoskeletal organization. The AND2 protein can also modulate gene expression and signaling pathways through its interactions with transcription factors and co-regulators.

Can the AND2 protein be targeted for therapeutic interventions in cardiac diseases?

There is ongoing research exploring the potential of targeting the AND2 protein for therapeutic interventions in cardiac diseases. However, additional studies are needed to establish the efficacy and safety of such interventions.

What are the cellular functions of the AND2 protein?

The AND2 protein, also known as actinin alpha cardiac muscle 2 or alpha-actinin 2, is primarily involved in maintaining the structure and integrity of the sarcomere, which is the structural unit of muscle fibers. It crosslinks actin filaments and anchors them to the Z-discs, contributing to the organization and stability of the contractile apparatus in cardiac muscle cells.

Is the AND2 protein involved in calcium signaling?

Yes, the AND2 protein is involved in regulating calcium signaling, which is essential for proper heart function.

Is the expression of the AND2 gene restricted to cardiac muscle cells?

While the AND2 gene is primarily expressed in cardiac muscle cells, it is also found in other tissues, including skeletal muscle, smooth muscle, and certain neuronal cells. However, its expression levels and functions may differ across different cell types.

What disorders can result from mutations in the AND2 gene?

Mutations in the AND2 gene can lead to various cardiac disorders, such as dilated cardiomyopathy and hypertrophic cardiomyopathy.

Where is the AND2 protein expressed?

The AND2 protein is specifically expressed in cardiac muscle tissues.

Are there any known interactions between the AND2 protein and other proteins?

Yes, the AND2 protein interacts with several other proteins involved in cardiac muscle function, including myosin, troponin, and actin.

Is there ongoing research to further understand the role of the AND2 protein and develop targeted therapies?

Yes, researchers are actively studying the role of the AND2 protein in cardiac development and disease. Through these studies, they aim to gain a deeper understanding of the molecular mechanisms underlying the function of AND2 and identify potential therapeutic targets for cardiac disorders associated with AND2 gene mutations.

Are there any diseases or disorders associated with mutations in the AND2 gene?

Yes, mutations in the AND2 gene have been associated with various cardiac disorders, including dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). These mutations can disrupt the proper assembly and functioning of the sarcomere, leading to impaired cardiac muscle contraction.

Are there any known genetic polymorphisms in the AND2 gene?

Yes, there have been studies identifying genetic polymorphisms in the AND2 gene that may be associated with an increased risk of certain cardiac disorders.

What are the consequences of AND2 gene mutations in individuals with dilated cardiomyopathy or hypertrophic cardiomyopathy?

AND2 gene mutations can lead to structural abnormalities in the sarcomere, impairing proper contraction of the cardiac muscle. In dilated cardiomyopathy, the heart chambers become enlarged and weakened, resulting in reduced pumping efficiency. Hypertrophic cardiomyopathy, on the other hand, is characterized by the thickening of the heart muscle, which can obstruct blood flow and lead to symptoms such as chest pain, shortness of breath, and arrhythmias.

Are there any therapeutic strategies being explored to target AND2 gene mutations?

While there are currently no specific therapies targeted at AND2 gene mutations, treatment strategies for dilated cardiomyopathy and hypertrophic cardiomyopathy generally focus on symptom management, improving heart function, and preventing complications. This can include medications to manage blood pressure and heart rhythm, lifestyle modifications, and in severe cases, surgical interventions such as implantable cardioverter-defibrillators or heart transplant.

How does the AND2 protein contribute to muscle contraction?

The AND2 protein helps in the organization and stability of the thin filaments in cardiac muscles, which are vital for muscle contraction.

Can the expression of the AND2 protein be regulated by external factors?

Yes, the expression of the AND2 protein can be regulated by various external factors, such as hormones, growth factors, and mechanical stress.