Recombinant Zebrafish ARF3B
Cat.No. : | ARF3B-2004Z |
Product Overview : | Recombinant Zebrafish ARF3B full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | arf3b ADP-ribosylation factor 3b [ Danio rerio (zebrafish) ] |
Official Symbol : | ARF3B |
Gene ID : | 368822 |
mRNA Refseq : | NM_001012248 |
Protein Refseq : | NP_001012248 |
UniProt ID : | Q78AP9 |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (21)
Ask a questionThe known interacting partners of ARF3B include various effector proteins involved in vesicular trafficking and cytoskeletal dynamics. These include adaptors, such as AP-1 and AP-3, which mediate protein trafficking between intracellular compartments. ARF3B can also interact with specific GEFs (guanine nucleotide exchange factors) and GAPs (GTPase activating proteins) that regulate its activation and inactivation, respectively.
The ARF3B protein is involved in vesicular trafficking, playing a role in the formation, budding, and fusion of transport vesicles. It regulates membrane remodeling and dynamics, facilitating the transport of cargo between different cellular compartments. Additionally, ARF3B has been implicated in cytoskeleton organization and cellular processes related to cell adhesion and migration.
Yes, ARF3B can undergo post-translational modifications that can impact its function and stability. Examples of such modifications include phosphorylation, ubiquitination, and acetylation. These modifications can regulate ARF3B's interactions with other proteins, its subcellular localization, and its ability to transduce signals within cells.
Currently, there are no known small molecules specifically targeting ARF3B activity. However, there are compounds and drugs available that can indirectly affect ARF3B function by targeting upstream regulators or downstream effectors of ARF3B signaling pathways. Targeting ARF3B itself with small molecules remains an area for future research and drug development.
As of now, there are no known pharmaceutical agents or compounds specifically targeting the ARF3B protein. However, compounds that broadly affect vesicular trafficking, such as inhibitors of specific steps in the process, may indirectly affect ARF3B-mediated functions. Development of selective modulators targeting ARF3B specifically could be an area of future investigation.
Currently, there is limited evidence available concerning the involvement of ARF3B in cancer development. However, some studies have suggested that dysregulation of ARF proteins, including ARF3B, may contribute to tumor progression and metastasis due to their role in vesicular trafficking and cytoskeletal dynamics. Further research is needed to explore the potential implications in cancer biology.
Yes, the ARF3B protein is conserved across different species. It is found in various organisms, indicating its importance and evolutionary relevance in cellular processes.
The expression of ARF3B can vary across different tissues and organs. It is often found to be ubiquitously expressed in various cell types due to its involvement in fundamental cellular processes. However, certain tissues or organs may exhibit higher levels of ARF3B expression depending on their specific functional requirements for vesicular trafficking or cytoskeleton organization.
Currently, there is limited knowledge regarding specific genetic or disease associations with the ARF3B protein. However, as ARF proteins are involved in fundamental cellular processes, dysregulation of ARF3B function or expression could potentially contribute to pathological conditions. Further research is needed to explore any such associations.
The exact role of ARF3B in embryonic development has not been extensively studied. However, as ARF3B is involved in various cellular processes essential for embryogenesis, its presence and proper functioning may be required for normal development. Further research is necessary to determine the specific contribution of ARF3B to embryonic development.
While ARF3B is primarily known for its role in vesicular trafficking and cytoskeletal dynamics, it is possible that it may have additional functions in other cellular processes. However, these potential functions have not been extensively characterized, and further research is needed to uncover any additional roles of ARF3B.
Yes, the ARF3B protein can participate in signaling pathways. It can act as a downstream effector of various signaling cascades, such as those initiated by receptor tyrosine kinases or G protein-coupled receptors. ARF3B can transduce signals to regulate vesicular trafficking events or cytoskeletal rearrangements associated with specific signaling processes.
The involvement of ARF3B in cancer progression and metastasis has not been extensively studied. However, some evidence suggests that ARF3B might be implicated in cellular processes related to cancer, such as cell migration and invasion. Further research is needed to determine the precise role of ARF3B in cancer and its potential as a therapeutic target.
Currently, there is limited information on genetic variants or mutations specifically in the ARF3B gene associated with human diseases. However, mutations or dysregulation of genes involved in vesicular trafficking and cytoskeletal dynamics, like ARF3B, have been implicated in various disorders, including neurological and cardiovascular diseases. It would be worthwhile to investigate if any genetic alterations in ARF3B are linked to human diseases.
There is currently no known information on mutations in the ARF3B gene leading to any specific genetic disorders. However, genetic variations or mutations affecting ARF3B or its regulatory components could potentially impact cellular processes dependent on ARF3B function.
Yes, ARF3B has been implicated in signal transduction pathways. It can modulate the activity of downstream effectors, such as phospholipase D (PLD) and phosphatidylinositol 4-phosphate 5-kinase (PIP5K), which are involved in generating second messengers important for cellular signaling. ARF3B's function in these pathways can influence various cellular processes, including cell proliferation, vesicle trafficking, and cytoskeletal reorganization.
Currently, there is limited research specifically focusing on the role of ARF3B in neurodegenerative diseases. However, since ARF3B is involved in vesicular trafficking and cytoskeletal dynamics, both of which are crucial for neuronal function and maintenance, it is plausible that dysregulation of ARF3B could contribute to neurodegenerative processes. More studies are needed to explore this potential association.
Currently, there is insufficient evidence to support the use of ARF3B as a biomarker in clinical practice. However, given its involvement in cellular processes, it remains a potential candidate for further investigation. Similarly, the development of therapies targeting ARF3B would require a better understanding of its precise functions and regulatory mechanisms.
Yes, ARF3B has been shown to interact with actin-binding proteins, such as WAVE2 and coronin-1B, suggesting its involvement in actin dynamics. Through these interactions, ARF3B may play a role in regulating actin filament assembly and disassembly, contributing to cytoskeletal remodeling processes.
Yes, the ARF3B protein can interact with various binding partners to carry out its functions. It interacts with effector proteins involved in vesicle formation and trafficking, such as coat proteins and regulators of vesicle budding. It can also interact with components of the cytoskeleton and signaling molecules that contribute to its role in cellular processes.
Yes, ARF3B can interact with other members of the ARF (ADP-ribosylation factor) family, such as ARF1, ARF4, and ARF5. These interactions can regulate ARF activation and the formation of protein complexes involved in intracellular trafficking. The specific functional consequences and significance of these interactions may vary depending on the cellular context and the specific ARF family members involved.
Customer Reviews (8)
Write a reviewOne notable advantage of using the ARF3B protein is the outstanding technical support provided by its manufacturer.
Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.
In addition to its scientific merits, the manufacturer of ARF3B protein stands out for its outstanding technical support.
The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.
The ARF3B protein is of exceptional quality, making it an ideal choice to meet my experimental needs.
The ARF3B protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.
Its unique properties make ARF3B an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.
With the ARF3B protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.
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