Recombinant Zebrafish ARF4B
Cat.No. : | ARF4B-2465Z |
Product Overview : | Recombinant Zebrafish ARF4B full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | arf4b ADP-ribosylation factor 4b [ Danio rerio (zebrafish) ] |
Official Symbol : | ARF4B |
Gene ID : | 550402 |
mRNA Refseq : | NM_001017707 |
Protein Refseq : | NP_001017707 |
UniProt ID : | Q566Z9 |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (12)
Ask a questionAs of now, there are no specific animal models available for studying ARF4B. However, genetically engineered mice with mutations in other ARF family members, like ARF1 and ARF6, have been used to study the broader functions of ARF proteins. These models have provided valuable insights into the role of ARFs in developmental processes and disease pathogenesis. It is possible that future studies may develop animal models specifically targeting ARF4B to further understand its physiological functions.
Yes, ARF4B protein is primarily localized to the Golgi apparatus, which is a central hub for vesicle trafficking and protein modification in the cell. It is also found in vesicles that transport cargo between the Golgi and other intracellular compartments, including the endoplasmic reticulum and plasma membrane.
Currently, there is limited information on specific genetic mutations or polymorphisms in the ARF4B gene associated with diseases. However, alterations in ARF4B expression or function have been observed in certain cancers, suggesting a potential role in tumor development and progression. Further research is needed to uncover any disease-specific associations.
The presence of ARF4B in extracellular vesicles or exosomes has not been extensively studied. However, exosomes derived from various cell types are known to contain a diverse range of proteins involved in vesicle trafficking and secretion. As ARF4B is implicated in these processes, it is possible that it may also be found in extracellular vesicles or exosomes, but further investigation is required to confirm this.
Currently, there are no specific diseases directly associated with ARF4B mutations. However, disruptions in ARF protein family members, including ARF4, have been linked to rare genetic disorders like ARF-related intellectual disability syndrome. It remains to be determined if ARF4B mutations specifically contribute to any human diseases.
While the specific role of ARF4B in brain function or neurodevelopment is not well-studied, ARF4B has been implicated in neuronal protein trafficking and synaptic vesicle recycling. Dysfunction in these processes can impact neuronal communication and synaptic plasticity, potentially affecting brain development and function. Further research is necessary to elucidate the exact role of ARF4B in the brain.
Currently, there are no specific inhibitors or activators of ARF4B that have been developed for therapeutic purposes. However, small molecules targeting other ARF family members, such as ARF1, have been investigated as potential inhibitors of ARF-regulated processes.
Studies have shown dysregulation of ARF4B expression or activity in several types of cancer. It has been associated with increased cell proliferation, invasion, and metastasis. ARF4B may play a role in the reorganization of the Golgi apparatus, potentially promoting the secretion of pro-tumorigenic factors. Further research is needed to fully understand the mechanisms underlying ARF4B's contribution to cancer development and progression.
ARF4B, along with other ARF family members, plays a critical role in endosome-to-Golgi transport. It is involved in forming and maintaining the structure of the trans-Golgi network (TGN), as well as regulating the assembly of COPI-coated vesicles that mediate retrograde transport from endosomes to the TGN. ARF4B is recruited to endosomes by adapter proteins, such as AP-1, and facilitates the sorting of cargo proteins into vesicles for transport to the Golgi apparatus.
Yes, ARF4B can interact with various membrane-bound lipids, which is important for its membrane localization and function. ARF4B contains a lipid-binding domain called the lipid anchor motif, which enables its association with specific phosphoinositides, such as phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 3-phosphate (PI3P). These lipid interactions are crucial for ARF4B's recruitment to specific cellular membranes and its involvement in membrane trafficking processes.
ARF4B protein regulates various cellular processes, including vesicle formation, vesicle cargo sorting, and vesicle trafficking between different compartments within the cell. It is involved in the maintenance of Golgi apparatus structure and function.
The potential of targeting ARF4B protein for therapeutic interventions is an area of active investigation. As ARF4B plays a crucial role in vesicle trafficking, which is vital for cellular processes, modulating its activity could have implications for a wide range of diseases. However, currently, there are no specific drugs or therapies targeting ARF4B available.
Customer Reviews (8)
Write a reviewthe ARF4B protein offers exceptional quality.
Researchers can rely on the ARF4B protein's specificity and sensitivity to obtain accurate and reliable results.
The ARF4B protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.
This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.
Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.
In protein electron microscopy structure analysis, the ARF4B protein demonstrates outstanding performance.
the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the ARF4B protein.
researchers highly recommend the ARF4B protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.
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