Recombinant Zebrafish ARHGAP17A

• Cat.No.: ARHGAP17A-2368Z
• Product Overview: Recombinant Zebrafish ARHGAP17A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: arhgap17a Rho GTPase activating protein 17a [ Danio rerio (zebrafish) ]
• Official Symbol: ARHGAP17A
• Gene ID: 550254
• mRNA Refseq: NM_001017592
• Protein Refseq: NP_001017592
• UniProt ID: Q568G9

Reviews

01/27/2023

The ARHGAP17A protein's robustness and stability have contributed significantly to the success of my experiments, enabling precise and reproducible measurements.

07/25/2022

Its exceptional performance, in combination with its clear and distinct protein bands, make it an absolute must-have for researchers looking to achieve accurate and reliable results in their experiments.

04/21/2022

This flexibility enables researchers like myself to tailor ARHGAP17A protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.

02/09/2019

Its purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.

06/03/2017

Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.

12/11/2016

Whether it's troubleshooting, protocol optimization, or general inquiries, their knowledgeable and responsive team is readily available to assist and solve any problems that may arise during the experimental process.

08/04/2016

I highly recommend the ARHGAP17A protein for a variety of experimental applications.

01/25/2016

I highly recommend the ARHGAP17A protein for a wide range of research applications.

Q&As

Are there any known protein interactions of ARHGAP17A?

Yes, ARHGAP17A has been found to interact with several cellular proteins. For example, it can interact with focal adhesion kinase (FAK) and PAK1, which are involved in cell adhesion and cytoskeletal rearrangements. These interactions suggest a role for ARHGAP17A in modulating cell adhesion dynamics.

Is ARHGAP17A expression regulated in a tissue-specific manner?

Yes, studies have shown that the expression of ARHGAP17A can vary across different tissues. For example, higher levels of ARHGAP17A expression have been observed in the brain, while lower levels are found in other tissues such as the liver or kidney. This suggests that the regulation of ARHGAP17A expression may be tissue-specific.

Are there any diseases or disorders associated with ARHGAP17A?

Currently, there is limited research on the direct involvement of ARHGAP17A in specific diseases or disorders. However, dysregulation of Rho GTPases, which are regulated by ARHGAP17A, has been implicated in various conditions such as cancer, neurological disorders, and cardiovascular diseases. Future studies may uncover potential links between ARHGAP17A and specific diseases.

Are there any other isoforms or related proteins of ARHGAP17A?

Yes, there is a closely related protein called ARHGAP17B. ARHGAP17A and ARHGAP17B share a high sequence homology and similar domain architecture. Both proteins act as GAPs for RhoA and CDC42, suggesting functional redundancy or overlapping roles. However, more research is needed to fully understand the functional differences and regulatory mechanisms of ARHGAP17A and ARHGAP17B.

What cellular processes are regulated by ARHGAP17A?

ARHGAP17A plays a crucial role in several cellular processes, including cell migration, cell adhesion, cytoskeletal organization, and cell signaling. By deactivating RhoA and CDC42, it helps in maintaining cellular homeostasis and proper functioning.

How does ARHGAP17A function in cellular migration?

ARHGAP17A regulates cellular migration by modulating the activity of RhoA and CDC42, which are key regulators of cytoskeletal dynamics. Through its GAP activity, ARHGAP17A reduces RhoA and CDC42 signaling, leading to the proper coordination of actin cytoskeleton and cell migration processes.

Does ARHGAP17A have any post-translational modifications?

Currently, there is limited research on the post-translational modifications of ARHGAP17A. However, it is known that many proteins undergo various modifications such as phosphorylation, ubiquitination, or acetylation, which can influence their activity or stability. Further investigation is necessary to determine if ARHGAP17A undergoes any post-translational modifications.

Can ARHGAP17A be targeted for therapeutic purposes?

Given its involvement in cellular processes related to migration, adhesion, and cytoskeletal dynamics, ARHGAP17A may represent a potential therapeutic target. Modulating its activity could potentially impact diseases involving aberrant cell migration, such as cancer metastasis or certain vascular disorders. However, the development of specific and effective therapies targeting ARHGAP17A would require further research and validation.

Are there any animal models available to study the function of ARHGAP17A?

Currently, there are no specific ARHGAP17A knockout or transgenic animal models reported in the literature. However, the functional roles of ARHGAP17A in cell migration and cytoskeletal regulation have been investigated using cell culture models. Future studies may involve the development of animal models to further elucidate the in vivo functions of ARHGAP17A.

Are there any known mutations or genetic variations in the ARHGAP17A gene?

Limited information is available regarding mutations or genetic variations specifically in the ARHGAP17A gene. Further research is needed to better understand the genetic landscape and potential implications of ARHGAP17A mutations in human health or disease.

How is ARHGAP17A expression regulated in response to external stimuli or environmental factors?

The regulation of ARHGAP17A expression in response to external stimuli or environmental factors is not well understood. However, it is known that various signaling pathways, including those activated by growth factors, cytokines, or cellular stress, can influence the expression of Rho GTPases and their regulators. It is plausible that similar mechanisms may modulate ARHGAP17A expression, but further investigation is needed to clarify these regulatory processes.