Recombinant Zebrafish ARPC4L
Cat.No. : | ARPC4L-1097Z |
Product Overview : | Recombinant Zebrafish ARPC4L full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | arpc4l actin related protein 2/3 complex, subunit 4, like [ Danio rerio (zebrafish) ] |
Official Symbol : | ARPC4L |
Gene ID : | 445305 |
mRNA Refseq : | NM_001003762 |
Protein Refseq : | NP_001003762 |
UniProt ID : | Q6NZZ2 |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionYes, ARPC4L interacts with other subunits of the ARP2/3 complex, as well as actin-binding proteins and regulatory factors involved in actin dynamics. These interactions are crucial for the proper functioning of the ARP2/3 complex and actin cytoskeletal remodeling.
There are currently no known diseases specifically linked to ARPC4L mutations. However, abnormalities in actin dynamics and the ARP2/3 complex have been associated with neurological disorders like intellectual disability, autism spectrum disorders, and cerebral palsy, where ARPC4L may play a role.
The expression of ARPC4L can be regulated by various factors, including developmental cues, cellular stress, growth factors, and hormonal signaling. Specific transcription factors and epigenetic modifications can modulate ARPC4L gene expression.
Post-translational modifications, such as phosphorylation, have been reported to regulate the activity of ARPC4L and the ARP2/3 complex. Phosphorylation of certain residues on ARPC4L can modulate its association with other subunits and influence actin nucleation and branching.
As of now, there are no specific drugs or therapeutic interventions targeting ARPC4L. However, targeting ARPC4L indirectly by modulating actin dynamics or the ARP2/3 complex may have therapeutic implications for diseases involving aberrant actin cytoskeletal regulation.
While ARPC4 and ARPC4L are similar in structure, they have divergent functions and expression patterns. ARPC4 is ubiquitously expressed and is found in many tissues, while ARPC4L has a more restricted expression pattern and is primarily found in certain tissues like the brain and testis.
While the specific role of ARPC4L in cancer progression is not extensively studied, dysregulation of actin dynamics and the ARP2/3 complex has been implicated in tumor cell invasion and metastasis. Further research is needed to understand the potential involvement of ARPC4L in cancer.
Customer Reviews (3)
Write a reviewThe ARPC4L protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.
The ARPC4L protein comes highly recommended for its outstanding performance in ELISA assays.
Its ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.
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