Recombinant Zebrafish ARPC5B

• Cat.No.: ARPC5B-11553Z
• Product Overview: Recombinant Zebrafish ARPC5B full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: arpc5b actin related protein 2/3 complex, subunit 5B [ Danio rerio (zebrafish) ]
• Official Symbol: ARPC5B
• Gene ID: 399482
• mRNA Refseq: NM_201509
• Protein Refseq: NP_958917
• UniProt ID: Q7ZWH4

Reviews

02/20/2019

Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.

02/09/2017

Its consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.

07/10/2016

The ARPC5B protein's exceptional performance in ELISA and its successful application in protein electron microscopy structure analysis make it a highly reliable and recommended choice for researchers.

Q&As

Is ARPC5B involved in neuronal development?

Yes, ARPC5B plays a role in neuronal development and synaptic plasticity. It is involved in the formation of neuronal structures, such as dendritic spines, and influences the actin cytoskeleton dynamics necessary for proper neuronal connectivity.

Can ARPC5B interact with other proteins?

Yes, ARPC5B can interact with other subunits of the ARP2/3 complex and various actin-binding proteins. These interactions are essential for the proper functioning and regulation of actin polymerization and cellular morphogenesis.

Is ARPC5B expression tissue-specific?

ARPC5B is widely expressed in various tissues and cell types. However, its expression levels may differ across different tissues and can be influenced by developmental stage and physiological conditions.

Does ARPC5B play a role in cancer metastasis?

While specific studies on ARPC5B's role in cancer metastasis are limited, the ARP2/3 complex, which includes ARPC5B, is known to play a role in invasive properties of cancer cells, including their ability to migrate and metastasize. Therefore, it is possible that ARPC5B may contribute to cancer metastasis through its involvement in actin regulation.

How does ARPC5B contribute to cell migration?

ARPC5B helps in the regulation of actin dynamics required for cell migration. It promotes the formation of actin-rich membrane protrusions, such as lamellipodia, which facilitate the forward movement of migrating cells.

Are there any disease associations with ARPC5B mutations?

There is limited information regarding specific disease associations with ARPC5B mutations. However, given its critical role in actin regulation and cellular processes, mutations in ARPC5B could potentially contribute to developmental disorders or diseases characterized by abnormal cell migration and morphogenesis.

Can ARPC5B be targeted for therapeutic interventions?

As of now, there are no specific therapeutic interventions targeting ARPC5B. However, given its involvement in actin regulation and cellular processes important for disease progression, targeting proteins involved in actin dynamics and cellular motility, indirectly affecting ARPC5B function, may have therapeutic potential.

Can ARPC5B mutations lead to defects in organ development?

The direct impact of ARPC5B mutations on organ development is not well-documented. However, considering its role in cellular morphogenesis and actin regulation, mutations in ARPC5B could potentially contribute to defects in organ development. Further research is needed to fully understand the implications of ARPC5B mutations in this context.