Recombinant Zebrafish ARPC5LB

• Cat.No.: ARPC5LB-6977Z
• Product Overview: Recombinant Zebrafish ARPC5LB full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: arpc5lb actin related protein 2/3 complex, subunit 5-like, b [ Danio rerio (zebrafish) ]
• Official Symbol: ARPC5LB
• Gene ID: 556104
• mRNA Refseq: NM_001128686
• Protein Refseq: NP_001122158
• UniProt ID: B0S516

Reviews

11/16/2021

Incorporating this protein into scientific investigations undoubtedly enhances the reliability and effectiveness of research endeavors.

07/24/2018

This level of support instills trust and confidence in the product, facilitating smooth and successful experimentation.

12/01/2016

The ARPC5LB protein comes highly recommended for a variety of research applications.

Q&As

Where is ARPC5LB protein predominantly expressed in the human body?

The ARPC5LB protein is ubiquitously expressed in various tissues and cell types throughout the human body. However, it may exhibit differential expression levels in different cell types or during different developmental stages.

Does ARPC5LB play a role in cell motility and migration?

Yes, ARPC5LB is involved in cell motility and migration. As a subunit of the Arp2/3 complex, it helps to nucleate actin filaments and generate branched actin networks that drive cell protrusion and movement. It contributes to the formation of lamellipodia and filopodia, which are crucial for cell migration.

Are there any disease or disorder associations with ARPC5LB mutations?

Currently, no specific diseases or disorders have been directly linked to ARPC5LB mutations. However, dysregulation of the Arp2/3 complex and its subunits, including ARPC5LB, has been implicated in various pathological conditions such as cancer metastasis, immune disorders, and neurological disorders. Further research is needed to elucidate the potential role of ARPC5LB in these diseases.

Are there any known interacting proteins of ARPC5LB?

ARPC5LB interacts with other subunits of the Arp2/3 complex, including ARPC1A, ARPC2, ARPC3, ARPC4, and ARPC5A or ARPC5. It also interacts with actin-related proteins (Arps) such as ACTR2 (Arp2) and ACTR3 (Arp3). Additionally, it can interact with actin-binding proteins, signaling molecules, and cytoskeletal regulators to modulate actin-associated processes.

How is ARPC5LB expression regulated at the transcriptional level?

The transcriptional regulation of ARPC5LB expression is not extensively studied and specific transcription factors or regulatory elements that control its expression have not been identified. However, like other genes, ARPC5LB expression can be influenced by various cellular signals and conditions that activate or repress the activity of transcription factors involved in actin cytoskeleton regulation.