Recombinant Zebrafish ARRB2A

• Cat.No.: ARRB2A-12712Z
• Product Overview: Recombinant Zebrafish ARRB2A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: arrb2a arrestin, beta 2a [ Danio rerio (zebrafish) ]
• Official Symbol: ARRB2A
• Gene ID: 321378
• mRNA Refseq: NM_214681
• Protein Refseq: NP_999846
• UniProt ID: Q6PFK2

Reviews

05/30/2021

The ARRB2A protein stands out as a high-quality protein that perfectly caters to my experimental requirements.

04/24/2019

Incorporating the ARRB2A protein into research endeavors ensures accurate and comprehensive results, bringing us closer to unraveling the complexities of cellular processes.

12/08/2017

the ARRB2A protein is highly recommended for its superior performance in ELISA and its utility in protein electron microscopy structure analysis.

Q&As

What areas of research are currently focusing on ARRB2A?

Research on ARRB2A is relatively limited at this time. However, ongoing studies may aim to elucidate its specific functions, interaction partners, and its potential role in disease processes. Additionally, understanding the expression pattern of ARRB2A in different tissues and how it is regulated may be an area of interest for future research.

How is ARRB2A expressed in cells?

The expression of ARRB2A varies among different cell types and tissues. It can be regulated at the mRNA level through alternative splicing or post-translational modifications.

Is ARRB2A found primarily in certain tissues or cell types?

The tissue-specific expression pattern of ARRB2A is not yet well characterized. Studies have reported its presence in various tissues, including the brain, heart, and immune cells, suggesting its potential expression in multiple cell types. However, more research is needed to determine its abundance in specific tissues or cell types.

Are there any known post-translational modifications specific to ARRB2A?

Currently, there is limited information on post-translational modifications specific to ARRB2A. However, since it is a splice variant of ARRB2, it is possible that similar post-translational modifications, such as phosphorylation or ubiquitination, may occur on ARRB2A as well.

Are there any diseases or conditions associated with ARRB2A dysregulation?

Currently, there is limited information on any specific diseases or conditions directly linked to ARRB2A dysregulation. However, considering its potential involvement in GPCR signaling pathways, dysregulation of ARRB2A could potentially contribute to disorders related to abnormal GPCR signaling, such as certain types of cancer, cardiovascular diseases, or neurological disorders. Further investigation is necessary to fully understand its implications in disease pathology.

How is the expression of ARRB2A regulated?

The regulation of ARRB2A expression is not fully understood yet. It is known that alternative splicing of ARRB2 mRNA leads to the production of ARRB2A. Cellular factors and signaling pathways that influence alternative splicing may play a role in the regulation of ARRB2A expression.

How does ARRB2A contribute to GPCR signaling?

While the specific role of ARRB2A in GPCR signaling is not fully understood, it is believed to interact with GPCRs similarly to ARRB2. Upon agonist stimulation, ARRB2A, like ARRB2, may bind to activated GPCRs to initiate receptor desensitization, internalization, and downstream signaling modulation.