Recombinant Zebrafish ASAH1B

• Cat.No.: ASAH1B-10855Z
• Product Overview: Recombinant Zebrafish ASAH1B full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: asah1b N-acylsphingosine amidohydrolase (acid ceramidase) 1b [ Danio rerio (zebrafish) ]
• Official Symbol: ASAH1B
• Gene ID: 393549
• mRNA Refseq: NM_200577
• Protein Refseq: NP_956871
• UniProt ID: Q6PH71

Reviews

11/25/2020

I am certain of obtaining reliable and reproducible results, enabling me to contribute to scientific progress and make new discoveries.

10/10/2020

With the ASAH1B Protein, I have the confidence to generate critical insights and drive significant advancements in my field.

09/25/2017

It has been extensively used in protein-protein interaction studies, enzymatic assays, and structural analyses, showcasing its reliability and adaptability in diverse research areas.

Q&As

Does the ASAH1B protein have any known functional domains or motifs?

Yes, the ASAH1B protein contains a catalytic domain that is essential for its hydrolytic activity on ceramide substrates.

Is the ASAH1B protein found only in humans?

No, the ASAH1B protein is conserved among various organisms, including humans, mice, and other mammals.

Does the ASAH1B protein have any non-enzymatic functions?

While the primary function of the ASAH1B protein is enzymatic, there is ongoing research to explore any potential non-enzymatic roles it might play.

Are there any drugs or inhibitors that target the ASAH1B protein?

Currently, there are no known drugs or inhibitors specifically targeting the ASAH1B protein. However, research efforts are ongoing to identify potential therapeutic interventions.

What are the consequences of mutations or deletions in the ASAH1B gene?

Mutations or deletions in the ASAH1B gene can lead to an accumulation of ceramide, potentially causing disorders such as Farber disease, a rare genetic disorder characterized by excessive ceramide accumulation.

Does the ASAH1B protein have any association with diseases other than Farber disease?

Studies suggest that dysregulation of ASAH1B activity may also play a role in neurodegenerative diseases, cancer, and metabolic disorders. However, further research is needed to fully elucidate these associations.

How is the expression of the ASAH1B gene regulated?

The expression of the ASAH1B gene can be regulated by various factors, including transcription factors, epigenetic modifications, and signaling pathways, which might differ in different cell types and under specific physiological conditions.