Recombinant Zebrafish ASCL1A

• Cat.No.: ASCL1A-8820Z
• Product Overview: Recombinant Zebrafish ASCL1A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ascl1a achaete-scute family bHLH transcription factor 1a [ Danio rerio (zebrafish) ]
• Official Symbol: ASCL1A
• Gene ID: 30466
• mRNA Refseq: NM_131219
• Protein Refseq: NP_571294
• UniProt ID: Q90259

Reviews

11/02/2020

These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.

07/24/2019

Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.

05/28/2019

Its purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.

Q&As

Is ASCL1A associated with any human diseases?

ASCL1A dysregulation is associated with neurodevelopmental disorders, such as autism spectrum disorders and intellectual disability, where mutations or altered expression levels have been observed.

How does ASCL1A contribute to neurogenesis?

ASCL1A acts as a transcription factor that directs neural progenitor cells to differentiate into neurons during neurogenesis, playing a key role in the formation of the nervous system.

Is ASCL1A essential for the development of specific neuronal subtypes?

Yes, ASCL1A is crucial for the development of specific neuronal subtypes, including subtypes in the cerebral cortex, olfactory bulb, and autonomic ganglia.

Can ASCL1A induce cellular reprogramming?

ASCL1A, in combination with other transcription factors, has been shown to induce the reprogramming of somatic cells into neurons in vitro, demonstrating its potential for cell fate alteration.

Does ASCL1A have any role in adult neurogenesis?

ASCL1A's role in adult neurogenesis is less well-understood, as it is primarily active during embryonic development, but some studies suggest its presence in specific adult brain regions.

Can ASCL1A be targeted for therapeutic interventions or drug discovery?

ASCL1A is being explored as a potential therapeutic target in neurodevelopmental disorders. Modulating its activity may hold promise for developing therapeutic strategies.

Are there any known interacting partners of ASCL1A?

ASCL1A interacts with various proteins involved in neurodevelopment, including NEUROD1, TCF3, TLE1, and HDAC1.