Recombinant Zebrafish ATP2A2A

• Cat.No.: ATP2A2A-11200Z
• Product Overview: Recombinant Zebrafish ATP2A2A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a [ Danio rerio (zebrafish) ]
• Official Symbol: ATP2A2A
• Gene ID: 393940
• mRNA Refseq: NM_200965
• Protein Refseq: NP_957259
• UniProt ID: Q7ZW18

Reviews

05/28/2022

Its stability is very good, and it can meet the needs of different experiments and scientific research without worrying about the change and influence of its performance.

09/24/2020

The high efficiency of ATP2A2A, high safety and high expression level make it exhibit excellent performance in a variety of applications.

01/10/2019

The lower limit of detection of ATP2A2A in Western blot was significantly reduced.

Q&As

Which heart diseases are associated with ATP2A2A mutations?

ATP2A2A protein mutations are associated with abnormal myocardial systolic function, which may lead to heart diseases, such as heart failure and arrhythmia.

What is the regulatory mechanism of ATP2A2A protein?

The expression and activity of ATP2A2A protein are regulated by various mechanisms, including transcription factor regulation, phosphorylation modification and protein-protein interaction.

What are the structural features of the ATP2A2A protein?

The ATP2A2A protein is a transmembrane enzyme containing multiple transmembrane domains and a cytoplasmic terminal atpase active domain.

What is the role of phosphorylation of ATP2A2A in the development of heart disease?

The phosphorylation of ATP2A2A protein can regulate its activity, and the change of phosphorylation status may play an important role in the development of heart diseases, such as cardiac hypertrophy and myocardial fibrosis.

Which role of ATP2A2A protein in myocardial contraction?

The ATP2A2A protein participates in the diastolic phase of cardiomyocytes by transporting cytosolic calcium ions back to the sarcoplasmic reticulum and maintains the normal rhythm of myocardial contraction and relaxation.

In which tissues is ATP2A2A protein expressed?

ATP2A2A protein is mainly expressed in cardiomyocytes, especially in the sarcoplasmic reticulum of cardiomyocytes.