Recombinant Zebrafish CADM1A
Cat.No. : | CADM1A-6315Z |
Product Overview : | Recombinant Zebrafish CADM1A full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | cadm1a cell adhesion molecule 1a [ Danio rerio (zebrafish) ] |
Official Symbol : | CADM1A |
Gene ID : | 569931 |
mRNA Refseq : | NM_001113551 |
Protein Refseq : | NP_001107023 |
UniProt ID : | B0F6R0 |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCADM1A is constitutively expressed in both species, primarily in lymphoid tissues and the brain. In European seabass, it is associated with T lymphocytes and increases during the cell-mediated cytotoxic response. In seabream, it is linked to non-specific cytotoxic/natural killer-like cells and correlates with a strong innate cell-mediated cytotoxic response.
When comparing mouse and zebrafish genes, it was noted that intron loss had occurred in both species, resulting in the elongation of certain exons. For instance, zebrafish CAM1A and 1b exons 1 and 2 were found to be identical to mouse CADM1 exon 1. Additionally, mouse CADM4 exons 3 and 4 appeared to have merged into zebrafish exon 3 due to intron loss.
CADM1A transcript levels increased during the innate cell-mediated cytotoxic response but only in seabream HKLs. No such increase was observed in seabass head-kidney leucocytes .
The chromosomal location of the cadm1a gene was determined through radiation hybrid mapping, which placed it on linkage group 21 in zebrafish. This analysis was crucial because it helped confirm whether cadm1a was a duplicate arising from genome duplication and provided evidence of its orthology with related genes.
In European seabass, CADM1A exhibits the highest transcription levels in the liver, brain, thymus, and spleen. In gilthead seabream, CADM1A has the highest expression in the brain, followed by gills, gonad, and thymus.
Customer Reviews (3)
Write a reviewOur research has been elevated thanks to the outstanding quality of this product.
it consistently delivers exceptional results.
We couldn't be happier with the consistently excellent results this protein provides.
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