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Transmembrane ion channel family was defined in InterPro and Pfam as the family of tetrameric sodium, potassium, and calcium ion channels, in which two C-terminal transmembrane helices flank a loop which determines ion selectivity of the channel pore. This large group of ion channels apparently includes families The Voltage-gated Ion Channel (VIC) Superfamily, Inward Rectifier K Channel (IRK-C) Family, The Ryanodine-Inositol 1,4,5-triphosphate Receptor Ca2+ Channel (RIR-CaC) Family, and The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family of transporter classification.
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