BGN
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Official Full Name
biglycan
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Overview
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009] -
Synonyms
BGN; biglycan; PGI; DSPG1; PG-S1; SLRR1A; biglycan proteoglycan; bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; small leucine-rich protein 1A; dermatan sulphate proteoglycan I;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- 6×His
- His
- GST
- His (Fc)
- Avi
- SUMO
- Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BGN Related Articles
- BGN Related Research Area
BGN involved in several pathways and played different roles in them. We selected most pathways BGN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, CS/DS degradation, Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BGN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | CSPG5;CSPG4;BGNB;AGRN;B3GAT2;GPC1B;BGN;CSPG5B;BCAN |
| CS/DS degradation | VCAN;CSPG4;CSPG5B;CSPG5;NCAN;BCAN;VCANB;DCN;BGNA |
| Chondroitin sulfate biosynthesis | VCANB;VCAN;UST;CSPG4;BGNB;BGNA;CHST9;B3GAT2;BGN |
| Chondroitin sulfate/dermatan sulfate metabolism | CHST14;GPC6;B4GALT7;BCAN;UST;GPC1B;DSEL;CSPG5;VCAN |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | GPC5;GPC6;VCAN;BCAN;CSPG4;DCN;AGRN;NCAN;CSPG5 |
| Defective B3GAT3 causes JDSSDHD | DCN;GPC5;BGN;CSPG5;BCAN;NCAN;CSPG4;GPC6;VCAN |
| Defective B4GALT7 causes EDS, progeroid type | NCAN;BGN;CSPG4;BCAN;VCAN;GPC6;GPC5;DCN;CSPG5 |
| Defective CHST14 causes EDS, musculocontractural type | DCN;BCAN;BGN;CSPG5;CSPG4 |
BGN has several biochemical functions, for example, extracellular matrix binding, extracellular matrix structural constituent, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BGN itself. We selected most functions BGN had, and list some proteins which have the same functions with BGN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix binding | CD248;VEGFA;ITGAV;SID4;DMP1;GPR56;SPARC;SPP1;BGN |
| extracellular matrix structural constituent | MGP;CHI3L1;COL27A1A;COL5A2;PRELP;COL1A2;COL2A1A;COL11A1B;COL4A5 |
| glycosaminoglycan binding | EPYC;SPOCK2;BGN;SPOCK3;DCN;HABP2;TGFBR3;VIT;TGFBR2 |
BGN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BGN here. Most of them are supplied by our site. Hope this information will be useful for your research of BGN.
TLR4; TLR2; PCOLCE; vegfa mouse; NUDCD2; Tlr4; Tlr2; Enam; prfA; Ambn; Amelx; q7ard3_yerpe; q7cg01_yerpe; fabG7
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