CTBP1
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Official Full Name
C-terminal binding protein 1
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Overview
CtBP1 (C-terminal binding protein 1) was first recognized as a cellular factor that interacts with the C-terminal portion of adenovirus E1A, a protein involved in the transcriptional regulation of key cellular genes (1). CtBP1 is able to regulate gene act -
Synonyms
CTBP1; C-terminal binding protein 1; C-terminal-binding protein 1; BARS; brefeldin A ribosylated substrate; brefeldin A-ribosylated substrate; MGC104684;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CTBP1 Related Signal Pathway
CTBP1 involved in several pathways and played different roles in them. We selected most pathways CTBP1 participated on our site, such as Chronic myeloid leukemia, Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | MECOM;RAF1;ARAF;PIK3R5;SMAD4;PTPN11;AKT1;STAT5A;HDAC2 |
| Deactivation of the beta-catenin transactivating complex | TLE4;CBY1;RBBP5;SOX7;PYGO1;TLE3;SOX32;TLE1;BCL9 |
| Degradation of beta-catenin by the destruction complex | TLE3;AES;TLE4;TLE2;TLE3B;CTBP2;CTBP1;TLE1;FAM123B |
| Disease | TRAT1;PSTPIP2;DOCK2;VPS37A;AP1M2;HMGA1;ACAN;NUPL2;AP1S1 |
| Diseases of signal transduction | FGFR1OP2;CPSF6;HDAC5;TRIM24;FKBP1A;TNKS;FGFR1OP;STRA6;RBP4 |
| Notch Signaling Pathway | NUMBL;HDAC2;PTCRA;DLA;DTX3L;ADAM12;JAG2B;DTX3;KAT2B |
| Notch-mediated HES/HEY network | TLE1;HES6;GATA6;HEY1;MYOD1;YY1;RCAN1;BGLAP;CTBP1 |
CTBP1 has several biochemical functions, for example, NAD binding, NADH binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTBP1 itself. We selected most functions CTBP1 had, and list some proteins which have the same functions with CTBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | NDUFS2;CTBP2A;BDH2;GRHPR;GPD1;IDH2;UGDH;HIBADH;IDH3B |
| NADH binding | CTBP2A;CTBP1;CTBP2;QDPR |
| RNA polymerase II transcription corepressor activity | TBX15;SIN3AA;CTBP1;TXLNB;TBX18;TCERG1;HDAC1;UXT;RBBP8 |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | FAM213B;CTBP2L;MDH1B;HSD3B5;GPD1A;SDR42E1;CTBP1;TESCA;GRHPRB |
| protein C-terminus binding | PABPC1;BLOC1S2;HOMER3;PDZD11;PEX12;TAF13;MAP3K7;DLG1;RAD51 |
| protein binding | THAP7;C12orf43;PTH1R;PNMA2;AKT2;GALNT3;LRFN4;ARHGAP24;Artn |
| protein domain specific binding | ATP1A1;DDC;RAP2B;NR0B1;GABRR3;SKIL;ARL1;TUBA1A;MITD1 |
| protein homodimerization activity | TNNC1;G6PDX;AMBP;PTPRO;TYR;EIF2AK3;CARD8;PML;MTUS2 |
| repressing transcription factor binding | CTNNB1;HDAC4;SKI;MYC;RUNX2;CTBP1;KAT5;HMGB1;MAGEA2B |
| transcription factor activity, sequence-specific DNA binding | ELF2B;TADA3;THRB;ZNF550;RFXANK;SP3A;TCF7;SHOX;RBPJA |
| transcription factor binding | PPARG;KLF5;PARK7;MECP2;DIP2B;ZFPM1;HDAC5;NKX3-1;JUNBB |
CTBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTBP1.
HIC1; ZNF366; e1a_ade05; RBBP8; CTBP2; EBNA6; KLF4
- Q&As
- Reviews
Q&As (7)
Ask a questionCTBP1 is a transcriptional co-repressor, regulating gene expression.
Genetic changes in CTBP1 affect cell development and differentiation.
CTBP1 collaborates with transcription factors, influencing gene regulation.
CTBP1 is involved in developmental processes and cell differentiation.
Targeting CTBP1 could treat diseases with abnormal gene expression, including cancer.
It plays a key role in transcriptional repression, impacting gene activity.
Altered CTBP1 activity is associated with cancer progression.
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