Creative BioMart to Present at IMMUNOLOGY2024™|May 3-7, 2024|Booth #512 Learn More

CTDP1

Official Full Name

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Overview

This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Synonyms

CTDP1; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; FCP1; CCFDN; RNA polymerase II subunit A C-terminal domain phosphatase; serine phosphatase FCP1a; TFIIF-associating CTD phosphatase 1; CTD of POLR2A, phosphatase of, subunit 1; transcription factor IIF-associating CTD phosphatase 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|Myc

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CTDP1-2059H	Recombinant Human CTDP1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	CTDP1-4016M	Recombinant Mouse CTDP1 Protein	Mammalian Cell	His		Inquiry
Mouse	CTDP1-2046M	Recombinant Mouse CTDP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	CTDP1-2204M	Recombinant Mouse CTDP1 Protein (178-341 aa), His-Myc-tagged	E.coli	His/Myc	178-341 aa	Inquiry
Mouse	CTDP1-2046M-B	Recombinant Mouse CTDP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CTDP1-861Z	Recombinant Zebrafish CTDP1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CTDP1 involved in several pathways and played different roles in them. We selected most pathways CTDP1 participated on our site, such as Abortive elongation of HIV-1 transcript in the absence of Tat, Disease, Formation of HIV elongation complex in the absence of HIV Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTDP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Abortive elongation of HIV-1 transcript in the absence of Tat	TH1L;CTDP1;SUPT5H;WHSC2;SUPT4H1;COBRA1;RDBP
Disease	CTDP1;CCDC59;CYP11A1;NUP50;OPN1MW2;AP1M2;OGN;TICAM1;TH1L
Formation of HIV elongation complex in the absence of HIV Tat	SUPT4H1;COBRA1;CDK9;WHSC2;ELL;SSRP1;TCEB3;TCEA1;RDBP
Formation of HIV-1 elongation complex containing HIV-1 Tat	SSRP1;RDBP;WHSC2;SUPT4H1;TCEA1;TH1L;TCEB3;CDK9;ELL
Formation of RNA Pol II elongation complex	PSTPIP2;RDBP;GM3258;CDK9;CCNT2A;TH1L;TCEB3;SUPT4H1;NELFE
Formation of the Early Elongation Complex	GM3258;SUPT4H1;COBRA1;WHSC2;SUPT5H;TH1L;RDBP;NELFE;CTDP1
Formation of the HIV-1 Early Elongation Complex	TH1L;SUPT4H1;SUPT5H;RDBP;WHSC2;COBRA1;CTDP1
Gene Expression	ZNF583;ZFP473;ELL;GTF3AA;ZNF74;METTL14;CHD4;ZBTB8OS;NR1I2

CTDP1 has several biochemical functions, for example, CTD phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTDP1 itself. We selected most functions CTDP1 had, and list some proteins which have the same functions with CTDP1. You can find most of the proteins on our site.

Function	Related Protein
CTD phosphatase activity	CTDSPLA;CTDSP2;CTDP1;CTDSP1;CTDSPLB;PPM1M;SSU72;CTDSPL;RPAP2
protein binding	KRTAP12-1;ZNF207;HSPA12B;PRDM5;NOTCH2;TYROBP;PRKCB;ASTE1;LAGE3

CTDP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTDP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTDP1.

PRMT5; POLR2B; ERH; STK38; POLR2A; WDR77; tktA; eno; Setdb1; LTN1; ETS2; CDK8; POLR2F; POLR2G