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CYP2A13

Official Full Name

cytochrome P450, family 2, subfamily A, polypeptide 13
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Synonyms

CYP2A13; cytochrome P450, family 2, subfamily A, polypeptide 13; cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 13; cytochrome P450 2A13; CPAD; CYP2A; CYPIIA13; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP2A13-2256H	Recombinant Human CYP2A13 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CYP2A13-433HCL	Recombinant Human CYP2A13 cell lysate		N/A		Inquiry
Human	CYP2A13-34H	Active Recombinant Human CYP2A13 Protein	E.coli			Inquiry
Human	CYP2A13-72H	Active Recombinant Human CYP2A13 Protein	E.coli			Inquiry
Human	CYP2A13-2345HF	Recombinant Full Length Human CYP2A13 Protein, GST-tagged	In Vitro Cell Free System	GST	494 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

CYP2A13 involved in several pathways and played different roles in them. We selected most pathways CYP2A13 participated on our site, such as Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Aflatoxin B1 metabolism	CYP2A13;CYP1A2;PRKRA;CYP3A4;FAM84B
Aflatoxin activation and detoxification	CYP2Y3;DPEP1;PRKRA;ACY3;CYP3A5;CYP1A2;CYP3C1;GGTLC1;GGT6
Biological oxidations	FDXR;CYP2K16;ADH6;CYP3A7-CYP3AP1;ABHD10;CYP19A1;CYP2K17;CYP2A13;CYP4B1
CYP2E1 reactions	CYP2B6;CYP2Y3;CYP2E1;CYP2A6;CYP2A7;CYP2C19;CYP2A13;CYP2S1;CYP2C8
Chemical carcinogenesis	FAM84B;UGT1A6B;GSTA5;AHA-1;CYP2C54;MGST1;GSTA1;GSTM7;MGST3
Cytochrome P450 - arranged by substrate type	CYP2A7;CYP2E1;CYP11B1;CYP2C19;CYP2C9;FDXR;CYP2AD2;CYP17A1;CYP3A4
Fatty acids	CYP4B1;CYP2B6;CYP4F12;CYP2J2;CYP2V1;CYP2AD2;CYP4T8;CYP2A13;CYP4A11
Metabolism	SULT1C4;CYP27B1;MAPK1IP1L;KHK;ACOT11;GLYATL2;IVD;SYT5;NAALAD2

CYP2A13 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A13 itself. We selected most functions CYP2A13 had, and list some proteins which have the same functions with CYP2A13. You can find most of the proteins on our site.

Function	Related Protein
arachidonic acid epoxygenase activity	CYP2C18;CYP2D26;CYP2B6;CYP2A7;CYP2AA12;CYP2AA1;CYP2F2;CYP2AD2;CYP2A6
aromatase activity	CYP2C55;CYP2F1;CYP2C70;CYP1D1;CYP2J6;CYP2S1;CYP4X1;CYP2A7;CYP2C38
heme binding	CYCS;IDO1;HBA-X;PTGS2A;FA2H;HBB-BH1;CYP24A1;HBE;CYP4B1
iron ion binding	CYP4F11;NOS3;CYP2A7;CYP8B1;CYP2J6;PDF;CYP4F3;HIF1AN;FBXL5
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2V1;CYP1B1;CYP2C55;CYP2AA4;CYP2AD2;CYP2P10;CYP2C54;CYP2AD6;CYP2C19
oxygen binding	HBB;HBA-X;CYP2X7;CYP2P10;TH;CYP2C55;CYP2X8;CYP2P6;CYP2C50
steroid hydroxylase activity	CYP2V1;CYP2C54;CYP2Y3;CYP2B19;CYP21A2;CYP1A1;CYP2B6;CYP2K19;CYP2A6

CYP2A13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2A13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2A13.

Research Area

Liu, ZH; Li, L; et al. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo. DRUG METABOLISM AND DISPOSITION 43:208-216(2015).

Chiang, HC; Wang, CK; et al. Differential Distribution of CYP2A6 and CYP2A13 in the Human Respiratory Tract. RESPIRATION 84:319-326(2012).