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DAB2

  • Official Full Name

    Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

  • Overview

    This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms

    DAB2; Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila); DOC2; DOC-2; disabled homolog 2; differentially-expressed protein 2; disabled homolog 2, mitogen-responsive phosphoprotein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DAB2-2315H Recombinant Human DAB2 Protein, GST-tagged Wheat Germ GST
Human DAB2-7086HCL Recombinant Human DAB2 293 Cell Lysate HEK293 N/A
Human DAB2-2520HF Recombinant Full Length Human DAB2 Protein, GST-tagged In Vitro Cell Free System GST 770 amino acids
Human DAB2-3554H Recombinant Human DAB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DAB2-1985HFL Recombinant Full Length Human DAB2 Protein, C-Flag-tagged Mammalian cells Flag
Human DAB2-1306H Recombinant Human DAB2 Protein, His-tagged E.coli N-His Asn3-Thr129
Human DAB2-714H-B Recombinant Human DAB2 Protein Pre-coupled Magnetic Beads HEK293
Human DAB2-714H Recombinant Human DAB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DAB2-4287M Recombinant Mouse DAB2 Protein Mammalian Cell His
Mouse DAB2-2192M Recombinant Mouse DAB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dab2-2446M Recombinant Mouse Dab2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DAB2-2192M-B Recombinant Mouse DAB2 Protein Pre-coupled Magnetic Beads HEK293
Rat DAB2-1768R Recombinant Rat DAB2 Protein Mammalian Cell His
Rat DAB2-1426R Recombinant Rat DAB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DAB2-1426R-B Recombinant Rat DAB2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DAB2-11771Z Recombinant Zebrafish DAB2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DAB2 Related Articles
  • DAB2 Related Research Area

DAB2 involved in several pathways and played different roles in them. We selected most pathways DAB2 participated on our site, such as Endocytosis, Formation of annular gap junctions, Gap junction degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisSMAD3;SNF8;HSPA2;CHMP4A;AGAP2;AP2M1A;KITB;ARRB2A;RHOAC
Formation of annular gap junctions
Gap junction degradationMYO6;DAB2;MYO6A;MYO6B
Gap junction traffickingMYO6B;CX27.5;GJA8;GJA4;GJB2;MYO6;GJD3;GJA5;GJC1
Gap junction trafficking and regulationGJB4;GJC1;GJB3;GJB2;GJA4;CX27.5;GJA8;MYO6;GJB5
Membrane TraffickingGJB5;CX30.3;COPE;TMED10;TRAPPC10;TRAPPC4;EXOC8;CNIH;PPP6R3
TGF-beta Receptor Signaling PathwayCITED1;ZEB1B;CTCF;SNIP1;HOXD9A;COPS5;ACVRL1;JUNBA;MEF2AA
TGF-beta receptor signalingDAB2;STRAP;EIF2A;TGFBR3

DAB2 has several biochemical functions, for example, SMAD binding, cargo receptor activity, clathrin adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DAB2 itself. We selected most functions DAB2 had, and list some proteins which have the same functions with DAB2. You can find most of the proteins on our site.

Function Related Protein
SMAD bindingSKOR1B;SKIA;RNF111;FKBP1A;FOXH1;TGFBRAP1;MAGI2;SNW1;PURB
cargo receptor activity
clathrin adaptor activityDAB2;ARRB1;PICALM;LDLRAP1
protein C-terminus bindingRAD51;ECM1;XRCC4;KSR1;PRKAA1;TAX1BP3;CTBP1;MRE11A;VIM
protein bindingELOVL6;P2RX4;PPP1R7;CRCT1;ZNF41;SNX4;FAM212A;ZBTB2;TNFAIP1

DAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAB2.

GRB2; MYO6; LRP6

Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).
Gao, S; Bajrami, I; et al. Dsh Homolog DVL3 Mediates Resistance to IGFIR Inhibition by Regulating IGF-RAS Signaling. CANCER RESEARCH 74:5866-5877(2014).
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