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DUSP3

  • Official Full Name

    dual specificity phosphatase 3

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
  • Synonyms

    DUSP3; dual specificity phosphatase 3; vaccinia virus phosphatase VH1 related , VHR; dual specificity protein phosphatase 3; vaccinia H1-related phosphatase; vaccinia virus phosphatase VH1-related; dual specificity protein phosphatase VHR; serine/threonin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUSP3-2492H Active Recombinant Human Dual Specificity Phosphatase 3, His-tagged E.coli His 1-185aa
Human DUSP3-1207H Active Recombinant Human Dual Specificity Phosphatase 3 E.coli N/A
Human DUSP3-3217H Active Recombinant Human DUSP3 protein(Met1-Pro185) Insect Cells N/A Met1-Pro185
Human DUSP3-2939H Recombinant Human DUSP3 Protein, GST-tagged Wheat Germ GST
Human DUSP3-473H Recombinant Human DUSP3, Gly & Pro tagged Insect Cell His
Human DUSP3-28377TH Recombinant Human DUSP3 E.coli N/A
Human DUSP3-3807H Recombinant Human DUSP3, His & GST tagged Insect Cell His/GST
Human DUSP3-26911TH Recombinant Human DUSP3, His-tagged E.coli His 205 amino acids
Human DUSP3-001HCL Recombinant Human DUSP3 cell lysate Insect Cell N/A
Human DUSP3-2260H Recombinant Human DUSP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DUSP3-2781H Recombinant Human DUSP3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DUSP3-4109HF Recombinant Full Length Human DUSP3 Protein, GST-tagged In Vitro Cell Free System GST 144 amino acids
Human DUSP3-3664H Recombinant Human DUSP3 protein, GST-tagged E.coli GST 1-185 aa
Human DUSP3-2007H Recombinant Human DUSP3 Protein (Ser2-Pro185), N-His tagged E.coli N-His Ser2-Pro185
Mouse Dusp3-2689M Recombinant Mouse Dusp3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque DUSP3-1355R Recombinant Rhesus monkey DUSP3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DUSP3-1180R Recombinant Rhesus Macaque DUSP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DUSP3-1180R-B Recombinant Rhesus Macaque DUSP3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DUSP3 Related Research Area

DUSP3 involved in several pathways and played different roles in them. We selected most pathways DUSP3 participated on our site, such as Activated TLR4 signalling, ERK/MAPK targets, ERKs are inactivated, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated TLR4 signallingAPPA;TANK;SIGIRR;DHX9;CHST13;MAPK14;DUSP7;IRAK3;DUSP4
ERK/MAPK targetsDUSP3;DUSP3B
ERKs are inactivatedDUSP3B;DUSP3
Immune SystemTREM1;SRMS;CD200R4;RNF25;EIF4G2A;CLEC2B;KIF3C;ASB3;CYLD
Innate Immune SystemPOLR3F;ALCAMB;NLRP3;MGC174155;C1rb;DEFB121;GZMM;BFB;BTR30
MAP kinase activation in TLR cascadeNOD1;DUSP3B;TNIP2;DUSP3
MAPK signaling pathwayPDGFAA;MOS;MAP2K2A;FGF9;RAC1A;PPM1NB;CACNA1G;NLK1;MKNK1
MAPK targets/ Nuclear events mediated by MAP kinasesDUSP3B;DUSP3

DUSP3 has several biochemical functions, for example, MAP kinase phosphatase activity, protein kinase binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP3 itself. We selected most functions DUSP3 had, and list some proteins which have the same functions with DUSP3. You can find most of the proteins on our site.

Function Related Protein
MAP kinase phosphatase activityDUSP10;DUSP3B;DUSP3
protein kinase bindingCDC25B;IFNAR2;EEF1A2;STX1B;MAP3K2;GOLGA2;TSKS;CSPG4;CLTC
protein tyrosine phosphatase activityPTPN4A;MTMR1B;PTEN;PTPRU;PTPN2A;PTPRM;DUSP21;MTMR7A;MDP1
protein tyrosine/serine/threonine phosphatase activityPTP4A1;PTP4A2B;CDC14AB;CDC14B;DUSP22;MTMR2;SACM1LA;DUSP22B;DUSP3

DUSP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP3.

MAPK3; MAPK1; MCC; HLA-B; CASK; BNIP3L; NEUROD1; pi3p

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