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The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
EDN1; endothelin 1; endothelin-1; ET1; Big endothelin 1; Big endothelin-1; EDN 1; EDN1 protein; EDN1_HUMAN; Endothelin1; ET 1; ET-1; OTTHUMP00000039245; PPET 1; PPET1; Preproendothelin 1; Preproendothelin-1; Preproendothelin1; HDLCQ7