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   Your Position: Home >> EIF2B3

EIF2B3

Official Full Name

eukaryotic translation initiation factor 2B, subunit 3

Background

The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

EIF2B3; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD); translation initiation factor eIF-2B subunit gamma; EIF 2B; EIF2Bgamma; EI2BG_HUMAN; eIF 2B GDP GTP exchange factor subunit gamma; EIF-2B; eIF-2B GDP-GTP exchange factor subunit gamma; eukaryotic translation initiation factor 2B subunit 3 gamma; OTTHUMP00000010262; OTTHUMP00000010263