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EML1

Official Full Name

echinoderm microtubule associated protein like 1
Overview

Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

EML1; echinoderm microtubule associated protein like 1; EMAPL; echinoderm microtubule-associated protein-like 1; ELP79; EMAP; HuEMAP; EMAL1_HUMAN; EMAP-1; FLJ45033; HuEMAP-1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EML1-3281H	Recombinant Human EML1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EML1-28291TH	Recombinant Human EML1	Wheat Germ	N/A	815 amino acids	Inquiry
Human	EML1-6609HCL	Recombinant Human EML1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	EML1-148HF	Recombinant Full Length Human EML1 Protein	In Vitro Cell Free System		815 amino acids	Inquiry
Human	EML1-4244HF	Recombinant Full Length Human EML1 Protein, GST-tagged	In Vitro Cell Free System	GST	815 amino acids	Inquiry
Mouse	EML1-5179M	Recombinant Mouse EML1 Protein	Mammalian Cell	His		Inquiry
Mouse	EML1-2774M	Recombinant Mouse EML1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	EML1-2774M-B	Recombinant Mouse EML1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	EML1-2092R	Recombinant Rat EML1 Protein	Mammalian Cell	His		Inquiry
Rat	EML1-1749R	Recombinant Rat EML1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	EML1-1749R-B	Recombinant Rat EML1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	EML1-7792Z	Recombinant Zebrafish EML1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EML1 Related Articles

EML1 involved in several pathways and played different roles in them. We selected most pathways EML1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EML1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

EML1 has several biochemical functions, for example, calcium ion binding, microtubule binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EML1 itself. We selected most functions EML1 had, and list some proteins which have the same functions with EML1. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	PCDHGB4;VCANB;EMR1;PCDH1G31;EFHC1;RASGRP1;ATP2A1;FBLN7;CAPSL
microtubule binding	KIF25;WHAMM;KIFC3;NPSNL;VAPA;TRPV4;JAKMIP3;GOLSYN;CAMSAP1A
protein binding	SNX18;HHLA2;C1orf182;IRAK2;PHLDA1;XRCC2;Icosl;CXCL2;FBP2
tubulin binding	DAG1;RPS3;TPR;BIRC5;MAP1S;TPPP;MTAP4;RITA1;NCALD

EML1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EML1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EML1.

ISG20L2; NUDC

Kielar, M; Tuy, FPD; et al. Mutations in the gene EML1 / EMl1, neuronal progenitors and heterotopias in humans and mice. M S-MEDECINE SCIENCES 30:1087-1090(2014).

Cocas, L; Pleasure, SJ; et al. Wrong place, wrong time: ectopic progenitors cause cortical heterotopias. NATURE NEUROSCIENCE 17:894-895(2014).