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EPC1

Official Full Name

enhancer of polycomb homolog 1 (Drosophila)
Overview

This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Synonyms

EPC1; enhancer of polycomb homolog 1 (Drosophila); Epl1; enhancer of polycomb homolog 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EPC1-3364H	Recombinant Human EPC1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EPC1-566HCL	Recombinant Human EPC1 cell lysate		N/A		Inquiry
Human	EPC1-4278HF	Recombinant Full Length Human EPC1 Protein, GST-tagged	In Vitro Cell Free System	GST	813 amino acids	Inquiry
Mouse	EPC1-5235M	Recombinant Mouse EPC1 Protein	Mammalian Cell	His		Inquiry
Mouse	EPC1-2811M-B	Recombinant Mouse EPC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	EPC1-2811M	Recombinant Mouse EPC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EPC1 Related Articles
EPC1 Related Research Area

EPC1 involved in several pathways and played different roles in them. We selected most pathways EPC1 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	PADI6;C17orf81;ACTL6A;EP400;KAT5;PHF8;CARM1;ACTL6B;KDM7AB
Chromatin organization	SMARCC1B;EP400;SMYD3;TADA3;KDM2A;USP22;SUZ12A;KDM5A;SUDS3
HATs acetylate histones	DR1;RUVBL2;ANO9A;PHF15;ING5;JADE1;ZZZ3;ACTL6A;DMAP1

EPC1 has several biochemical functions, for example, contributes_to histone acetyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPC1 itself. We selected most functions EPC1 had, and list some proteins which have the same functions with EPC1. You can find most of the proteins on our site.

Function	Related Protein
contributes_to histone acetyltransferase activity	ELP4;TAF10;SUPT7L;KAT2A;TAF12;EPC1;TAF5L;TAF9;TAF6L
protein binding	CAND1;TP53RK;PYGB;RTN4RL2A;FHL5;OGN;NAA35;ZNF664-FAM101A;PROM1

EPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPC1.

RINT1; KRT15; MRGBP; ACTL6A; MYC; VPS72; RUVBL2; RUVBL1

Che, CL; Zhang, LJ; et al. RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:361-367(2015).

Lehman, HL; Yang, XB; et al. p120-Catenin Down-Regulation and Epidermal Growth Factor Receptor Overexpression Results in a Transformed Epithelium That Mimics Esophageal Squamous Cell Carcinoma. AMERICAN JOURNAL OF PATHOLOGY 185:240-251(2015).

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