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ESX1

Official Full Name

ESX homeobox 1
Overview

This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.
Synonyms

ESX1; ESX homeobox 1; ESX1L, extraembryonic, spermatogenesis, homeobox 1 homolog (mouse); homeobox protein ESX1; ESXR1; homeobox 1; spermatogenesis; Epx; ESX1_HUMAN; ESX1L; Etx; Extraembryonic; Extraembryonic spermatogenesis homeobox 1; Homeobox protein ESX1-C; Spx1; ESX1-related protein; extraembryonic, spermatogenesis, homeobox 1 homolog;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ESX1-12563H	Recombinant Human ESX1, His-tagged	E.coli	His	1-406a.a.	$319 / 25ug
Human	ESX1-3513H	Recombinant Human ESX1 Protein, GST-tagged	Wheat Germ	GST		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ESX1 Related Articles

ESX1 involved in several pathways and played different roles in them. We selected most pathways ESX1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells	HNF1A;LEFTY2;SOX2;INHBE;ID2;SMAD3;WNT2;DLX5;ZIC3

ESX1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, sequence-specific DNA binding, transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESX1 itself. We selected most functions ESX1 had, and list some proteins which have the same functions with ESX1. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II regulatory region sequence-specific DNA binding	ETV5;NHLH1;DMRT1;MEF2C;ZNF256;STAT4;GATA2B;BARX1;POGZA
sequence-specific DNA binding	GATA5;IKZF4;RAG1;RXRAB;ZNF238;ZNF831;GRHL1;HOXC12A;ZNF165
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	MITF;VAX2;ZC3H8;FOXD3;HES6;DMBX1;ZBTB4;FEZF2;CSDA

ESX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESX1.

kras_human_dna_51bp_intronic; Dlg4; TRAP1; EXOC2; kras_human_gene

Pansa, A; Sirchia, SM; et al. ESX1 mRNA expression in seminal fluid is an indicator of residual spermatogenesis in non-obstructive azoospermic men. HUMAN REPRODUCTION 29:2620-2627(2014).

Solans, L; Gonzalo-Asensio, J; et al. The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis. PLOS PATHOGENS 10:-(2014).