folh1
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  • Official Full Name
  • folate hydrolase (prostate-specific membrane antigen) 1
  • Background
  • This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
  • Synonyms
  • FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I;
Cat.#:FOLH1-7844HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOLH1 protein, His-tagged
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Cat.#:Folh1-7845MTag:His & T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Folh1 protein, His & T7-tagged
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Cat.#:FOLH1-2415HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FOLH1, His-tagged
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Cat.#:FOLH1-2416HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FOLH1 protein, His-tagged
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Cat.#:FOLH1-31003THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOLH1
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Cat.#:Folh1-907MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Folh1, His tagged
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Cat.#:FOLH1-2379RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FOLH1 Protein
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Cat.#:FOLH1-2414HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Folate Hydrolase, GST-tagged
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Cat.#:FOLH1-2452MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FOLH1 cell lysate
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FOLH1 Related Articles

Haffner, MC; Laimer, J; et al. High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity. MODERN PATHOLOGY 25:1079-1085(2012).
Haffner, MC; Kronberger, IE; et al. Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. HUMAN PATHOLOGY 40:1754-1761(2009).