gdi1
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  • Official Full Name
  • GDP dissociation inhibitor 1
  • Background
  • GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family,;small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between;cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound;rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked;nonspecific mental retardation.
  • Synonyms
  • GDI1; GDP dissociation inhibitor 1; rab GDP dissociation inhibitor alpha; FLJ41411; GDI-1; GDIA_HUMAN; Guanosine diphosphate dissociation inhibitor 1; Mental retardation X-linked 41; Mental retardation X-linked 48; MRX41; MRX48; Oligophrenin 2; Oligophrenin-2; OPHN2; Protein XAP 4; Protein XAP-4; Protein XAP4; Rab GDI alpha; RABGD1A; RABGDIA; XAP 4; SMG p25A GDI
Cat.#:GDI1-4831HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GDI1 Protein, GST-tagged
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Cat.#:GDI1-640HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GDI1 Protein, MYC/DDK-tagged
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Cat.#:GDI1-196HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDI1, His-tagged
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Cat.#:GDI1-6291MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GDI1 Protein
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Cat.#:GDI1-2504RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GDI1 Protein
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Cat.#:GDI1-542CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GDI1 Protein, His-tagged
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Cat.#:GDI1-715BTag:
Source (Host):Insect cellSpecies:Bovine
Product nameRecombinant Bovine GDI1 Protein
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Cat.#:GDI1-2787ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GDI1
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Cat.#:GDI1-1120BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine GDP Dissociation Inhibitor 1
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Cat.#:GDI1-5965HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GDI1 293 Cell Lysate
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Involved Pathway

GDI1 involved in several pathways and played different roles in them. We selected most pathways GDI1 participated on our site, such as Integrated Breast Cancer Pathway, Rho GTPase cycle, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDI1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Integrated Breast Cancer Pathway
GRN; MYT1; CYP19A1; UBE2F; EDAR; DAG1; SELK; USP38; RPP38; ALKBH1
Rho GTPase cycle
ARHGAP11A; ARHGAP6; ARHGAP36; DEPDC1B; RALBP1; ARHGAP25; RHOV; RHOT1A; MCF2L; ARHGAP8
Signal Transduction
OXGR1A.2; FGD4A; USP15; APOA4B.2; ROR2; PDK3; RXFP2B; NRP2B; CCK; RTN4A
Signaling by Rho GTPases
DEPDC7; ARHGAP31; FGD2; ARHGAP26; KTN1; FMNL2; ARHGAP1; ARHGAP23; ARAP2; ARHGAP19
Signaling mediated by p38-alpha and p38-beta
GDI1; KRT8; USF1; HBP1

Protein Function

GDI1 has several biochemical functions, for example, GDP-dissociation inhibitor activity, GTPase activator activity, Rab GDP-dissociation inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDI1 itself. We selected most functions GDI1 had, and list some proteins which have the same functions with GDI1. You can find most of the proteins on our site.
Function
Related Protein
Function GDP-dissociation inhibitor activity
Related Protein GDI1; GPSM2L; RANBP1; GPSM1B; SH3BP4; ITGB1BP1; SH3BP4A; RGS14; GPSM1
Function GTPase activator activity
Related Protein ARHGAP4; ECT2; RAP1GAP; ARHGAP27; ALS2CL; RACGAP1; RIN1; ARHGEF15; RGS9B; TBC1D26
Function Rab GDP-dissociation inhibitor activity
Related Protein GDI1; GDI2
Function Rab GTPase binding
Related Protein PPIAL4A; RABGGTA; FER; EHD1; MLPHB; RABGEF1; AP3M1; UNC13D; NSF; MICALL1
Function oxidoreductase activity
Related Protein CYP4A10; PLOD1A; RDH14A; ADOA; CYP24A1; PDHA1B; OXNAD1; HSD11B1L; PYCR1A; ADH8B
Function protein binding
Related Protein ACTA1; LRP1; ILF2; SALL1; ATP2B4; PRDX6; LIMS3L; SLC25A5; RALBP1; LETMD1

Interacting Protein

GDI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDI1.
RAB4A; Rab10; RAB1A; LNX1; SPOP; HLA-B; YWHAZ; FBXO11; RAB24; FTSJ1; TK1; GNL1; dppA

GDI1 Related Articles

Gallart-Palau, X; Serra, A; et al. Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia. NEUROCHEMISTRY INTERNATIONAL 80:87-98(2015).
D'Adamo, P; Masetti, M; et al. RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 46:302-314(2014).