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GNB3

Official Full Name

guanine nucleotide binding protein (G protein), beta polypeptide 3
Overview

G-Protein b3 (GNB3) is a guanine nucleotide-binding protein (G protein). G-proteins are involved as a modulator or transducer in various transmembrane signaling systems.
Synonyms

GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; transducin beta chain 3; G protein, beta-3 subunit; hypertension associated protein; GTP-binding regulatory protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GNB3-299H	Recombinant Human guanine nucleotide binding protein (G protein), beta polypeptide 3, His-tagged	E.coli	His		Inquiry
Human	GNB3-5861HCL	Recombinant Human GNB3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GNB3-5370HF	Recombinant Full Length Human GNB3 Protein, GST-tagged	In Vitro Cell Free System	GST	340 amino acids	Inquiry
Human	GNB3-5056H	Recombinant Human GNB3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Rat	GNB3-2602R	Recombinant Rat GNB3 Protein	Mammalian Cell	His		Inquiry
Rat	GNB3-2257R	Recombinant Rat GNB3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GNB3-2257R-B	Recombinant Rat GNB3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	GNB3-1898R	Recombinant Rhesus monkey GNB3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	GNB3-1718R	Recombinant Rhesus Macaque GNB3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	GNB3-1718R-B	Recombinant Rhesus Macaque GNB3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

GNB3 involved in several pathways and played different roles in them. We selected most pathways GNB3 participated on our site, such as Ras signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	FOXO4;ETS1;SHC4;RAPGEF5;RELA;RAC2;PIK3R2;PLA2G4F;NGFR
Chemokine signaling pathway	CCL17;SHC3;CXCR2;Adcy4;PLCB2;BRAF;Cxcl15;CCL23;RAF1
PIK-Akt signaling pathway	ITGA8;GSK3B;GH1;FGF3;IFNA12;ITGA2B;CCND1;GNG7;LPAR6
Circadian entrainment	ITPR1;RYR1;GNG11;PLCB3;GNG4;GNG5;CALM3;GNGT1;CALM1
Retrograde endocannabinoid signaling	GABRA5;GNG7;MAPK11;GRIA1;Adcy4;PRKACA;GNG8;GABRG3;GABRG2
Glutamatergic synapse	SLC1A1;GNG3;GRIN2D;GNAI3;SLC17A8;GNG8;SLC38A1;PLA2G4C;HOMER3
Cholinergic synapse	PRKACB;GNG2;FOS;SLC5A7;CREB3;CAMK2G;PLCB2;CREB3L4;AKT2
Serotonergic synapse	SLC6A4;PTGS1;PTGS2;HTR3A;SLC18A1;GNAQ;SLC18A2;GNAO1;HRAS
GABAergic synapse	SLC38A1;GNGT2;GLS2;GABBR1;GNB3;SLC12A5;GABRR3;GABRA2;SLC38A2
Dopaminergic synapse	GNAO1;SLC6A3;KIF5B;CREB3L1;ATF6B;PPP2R5C;KCNJ6;PPP2R5A;MAPK10
Taste transduction	GNAS;ASIC2;TAS2R42;GNG13;GNG3;TAS2R109;GNB1;TAS2R113;TAS1R1
Alcoholism	HIST2H4;HIST1H4J;HIST1H2BC;HIST1H2AA;HDAC11;H3F3C;CALML3;H2AFY;SLC18A2
Pathways in cancer	DAPK2;GSK3B;FGFR1;TGFB2;PIK3R2;BCL2;GNAS;ITGAV;WNT6

GNB3 has several biochemical functions, for example, GTPase activity, GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB3 itself. We selected most functions GNB3 had, and list some proteins which have the same functions with GNB3. You can find most of the proteins on our site.

Function	Related Protein
GTPase activity	RHOG;EEF2;RRAGD;RAB5AA;DNM1;GBP3;RAP2A;GNA13;RAB32
GTPase binding	GNB3;LCP1;GNB2;STOML2;IARS;YBX1;RAB3D;MARCH5;BNIP3
protein binding	DIEXF;PHF7;SP140;ZNF18;INHBA;NCBP2;RRAGA;NPC1;LAMA1
signal transducer activity	GNAL;GNAI1;PLCL2;IL1R1;RGS9;NPFFR1L2;ADRB2A;GNA15.4;MAPKAPK2B

GNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB3.

CXCR5; NS; ERBB2; P; ESR2; CDC5L