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  • Official Full Name
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Background
  • The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
  • Synonyms
  • GNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; IBM2, UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Uae1; IBM2; 2310066H07Rik; Bifunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; DMRV; ManAc kinase; N acylmannosamine kinase; NM; RP23-209M8.6; UDP GlcNAc 2 epimerase; UDP GlcNAc 2 epimerase/ManAc kinase; Uridine diphosphate N acetylglucosamine 2 epimerase; N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; GLCNE
Cat.#:GNE-13359HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNE, His-tagged
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Cat.#:GNE-94HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human GNE, His-tagged
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Cat.#:GNE-2605RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNE Protein
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Cat.#:GNE-3081CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GNE
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Cat.#:GNE-11130ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GNE
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Cat.#:GNE-5858HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GNE 293 Cell Lysate
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GNE Related Articles

Weldon, RA; Fensin, ML; et al. Total neutron emission generation and characterization for a Next Generation Safeguards Initiative spent fuel library. PROGRESS IN NUCLEAR ENERGY 80:45-73(2015).
Broccolini, A; Mirabella, M; et al. Hereditary inclusion-body myopathies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:644-650(2015).