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GRIN2D

Official Full Name

glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Overview

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
Synonyms

GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; EB11; NR2D; GluN2D; NMDAR2D; glutamate receptor ionotropic, NMDA 2D; estrogen receptor binding CpG island; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; glutamate [NMDA] receptor subunit epsilon-4;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRIN2D-611H	Recombinant Human GRIN2D	Mammalian Cell	His		Inquiry
Human	GRIN2D-2216H	Recombinant Human GRIN2D Protein, His-tagged	E.coli	N-His	Phe28-Ala584	Inquiry
Human	GRIN2D-3078H	Recombinant Human GRIN2D Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	GRIN2D-3078H-B	Recombinant Human GRIN2D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GRIN2D-7273M	Recombinant Mouse GRIN2D Protein	Mammalian Cell	His		Inquiry
Mouse	GRIN2D-3932M	Recombinant Mouse GRIN2D Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GRIN2D-3932M-B	Recombinant Mouse GRIN2D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	GRIN2D-2703R	Recombinant Rat GRIN2D Protein	Mammalian Cell	His		Inquiry
Rat	GRIN2D-2357R	Recombinant Rat GRIN2D Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GRIN2D-2357R-B	Recombinant Rat GRIN2D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

GRIN2D involved in several pathways and played different roles in them. We selected most pathways GRIN2D participated on our site, such as Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	GRM5;PHKA1;TACR1B;ADORA2AA;ADRB1;SPHK2;P2RX3A;HTR2A;CHRM1
cAMP signaling pathway	MAP2K2;CREB3L3;PPARA;CAMK2B;PIK3CG;PPP1CC;NPY;MC2R;HCN4
Neuroactive ligand-receptor interaction	APLNRB;APLNR;AVPR2;IL12;PTGER1;P2RY1;TAAR12B;PTGER4B;DRD1B
Circadian entrainment	CALM3;GNB4;GRIN2A;PRKCG;GNG11;GRIA3;GNG7;GNG10;RASD1
Long-term potentiation	ITPR1;CAMK2A;PRKACB;PRKACA;GNAQ;PLCB3;PPP1CB;GRIN2B;PRKCA
Glutamatergic synapse	SLC38A3;SLC38A1;GNG4;ITPR1;Adcy4;GNB4;GRIK5;GRIA2;ADRBK2
Alzheimers disease	ATP5E;LPL;CALM3;FADD;ATP2A1;NAE1;NDUFS6;NDUFA6;NDUFS4
Amyotrophic lateral sclerosis (ALS)	NEFM;CASP9;CASP12;MAPK13;DERL1;TNFRSF1B;Casp3;CASP1;TP53
Cocaine addiction	GRIN2D;PRKACG;CREB3L2;MAOB;RELA;CREB5;FOSB;CREB3L3;ATF6B
Nicotine addiction	GABRG2;GABRD;GABRE;GABRA5;GRIA2;GABRG3;GABRB2;GABRA2;GRIN2D
Alcoholism	GM14479;CAMKK2;HIST1H3D;HIST2H2AC;PPP1CC;H2AFB3;HIST3H2BB;GNG8;H2AFB1

GRIN2D has several biochemical functions, for example, NMDA glutamate receptor activity, extracellular-glutamate-gated ion channel activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN2D itself. We selected most functions GRIN2D had, and list some proteins which have the same functions with GRIN2D. You can find most of the proteins on our site.

Function	Related Protein
NMDA glutamate receptor activity	GRIN1A;GRIN1B;GRIN3B;GRIN2B;GRIN3A;GRIN2A;GRIN2C;GRIN2BB;GRIN2D
extracellular-glutamate-gated ion channel activity	GRIA3B;GRIN2BB;GRIA1;GRIK4;GRIA4B;GRIK5;GRIN2C;GRIA1B;GRIN2B
protein binding	USE1;ZFP932;PROM1;MAPK3;HIC1;THBS2;FAM188A;ARHGEF16;WNK1

GRIN2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN2D here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN2D.

Dlg4; DLG4; Dlg3; CRK