GYS1
-
Official Full Name
glycogen synthase 1 (muscle)
-
Overview
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GYS1; glycogen synthase 1 (muscle); GYS; glycogen [starch] synthase, muscle; GSY;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Sf9 insect cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
GYS1 involved in several pathways and played different roles in them. We selected most pathways GYS1 participated on our site, such as Starch and sucrose metabolism, PIK-Akt signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GYS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Starch and sucrose metabolism | UGT1A6A;UGP2;G6PCA.2;PGM2;AMY1B;AGL;UGT1A7;AMY2A3;HK2 |
PIK-Akt signaling pathway | G6PC;AKT2;IFNA6;TEK;IBSP;PDPK1;TCL1B4;IFNA14;PPP2R1B |
AMPK signaling pathway | RPS6KB1;MTOR;RPTOR;PPP2R1A;GYS1;PPP2R2C;EEF2;PRKAG2;PRKAB1 |
Insulin signaling pathway | EIF4EA;EIF4E1C;PRKAR2A;BADB;PIK3R1;RPTOR;SHC2;RPS6KB1B;PKLR |
Insulin resistance | PPP1CAA;PPP1R3CA;GSK3AA;RPS6KB2;NFKB1;MTOR;PRKAB1;PTPRF;INS1 |
GYS1 has several biochemical functions, for example, glucose binding, glycogen (starch) synthase activity, glycogen synthase activity, transferring glucose-1-phosphate. Some of the functions are cooperated with other proteins, some of the functions could acted by GYS1 itself. We selected most functions GYS1 had, and list some proteins which have the same functions with GYS1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
glucose binding | SLC2A8;PYGL;HKDC1;HK3;GYS1;SLC2A3;G6PDX;HK2;G6PD |
glycogen (starch) synthase activity | GYS1;GYS2 |
glycogen synthase activity, transferring glucose-1-phosphate | GYS1;GYS2 |
protein binding | CARKD;PXMP2;RPL10;DPM1;LGALS14;CYTH3;C18orf56;NAA11;ORC1L |
protein kinase binding | MSH2;PAK2;STX1B;PTPN23;RAD9;RNF138;PTK2;B4GALT1;LIPE |
GYS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GYS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GYS1.
GYG1; GSK3B; AIMP2; CCDC36; GABARAPL1; PASK; PRKAB2
- Q&As
- Reviews
Q&As (7)
Ask a questionIt plays a significant role in maintaining blood glucose levels by regulating glycogen synthesis in response to hormonal signals.
Targeting GYS1 could provide new strategies for managing metabolic conditions, including glycogen storage diseases and diabetes.
Genetic mutations in GYS1 can lead to glycogen storage diseases, affecting glucose availability and energy balance.
GYS1, Glycogen Synthase 1, is crucial for the synthesis of glycogen, the primary storage form of glucose in the body.
Altered GYS1 activity can impact glycogen storage and glucose metabolism, contributing to disorders like diabetes.
GYS1 is vital for muscle and liver function, where it facilitates energy storage and release.
GYS1's activity is regulated by insulin and glucagon, which modulate glycogen synthesis in response to the body's energy needs.
Customer Reviews (3)
Write a reviewCritical for research success. Consistently trustworthy.
Dependable service. A research must-have.
Reliable data source. Elevates our research quality.
Ask a Question for All GYS1 Products
Required fields are marked with *
My Review for All GYS1 Products
Required fields are marked with *