hdgf
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  • Official Full Name
  • hepatoma-derived growth factor
  • Background
  • This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms
  • HDGF; hepatoma-derived growth factor; hepatoma derived growth factor (high mobility group protein 1 like); high mobility group protein 1 like; HMG1L2; HMG-1L2; high mobility group protein 1-like 2; FLJ96580; DKFZp686J1764
Cat.#:HDGF-4658HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDGF Protein, GST-tagged
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Cat.#:HDGF-27530THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDGF
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Cat.#:HDGF-29209THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDGF
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Cat.#:HDGF-620HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDGF protein, His & T7-tagged
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Cat.#:HDGF-7539MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDGF Protein
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Cat.#:Hdgf-75MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hdgf protein, His-tagged
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Cat.#:HDGF-2819RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HDGF Protein
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Cat.#:HDGF-361HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDGF
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Cat.#:HDGF-5598HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDGF 293 Cell Lysate
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Involved Pathway

HDGF involved in several pathways and played different roles in them. We selected most pathways HDGF participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with HDGF were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
IRE1alpha activates chaperones
CTDSP2; KDELR3; CXXC1; YIF1A; SERP1; DDX11; ADD1; PREB; DNAJB9; ASNA1
Metabolism of proteins
DPH2; SLC25A12; PFDN1; SMC5; DAD1; TRAPPC6BL; DNAJC24; TOMM22; KDELR3; TIMM21
Unfolded Protein Response (UPR)
YY2; SERP1; TPP1; YIF1A; ASNA1; KDELR3; FKBP14; PDIA6; KLHDC3; WIPI1
XBP1(S) activates chaperone genes
HYOU1; DDX11; TPP1; ASNA1; SEC63; PDIA6; FKBP14; KLHDC3; HDGF; CTDSP2

Protein Function

HDGF has several biochemical functions, for example, DNA binding, RNA polymerase II transcription corepressor activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HDGF itself. We selected most functions HDGF had, and list some proteins which have the same functions with HDGF. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein FOXO1A; ZNF225; TFDP2; RFX8; HOPX; HIST1H2BB; IRX1B; CERS5; MCM8; SIX1A
Function RNA polymerase II transcription corepressor activity
Related Protein TBX18; TFAP2B; NFIB; SIN3B; HDAC1; SIN3A; UXT; HDGF; SIN3AA; TXLNB
Function growth factor activity
Related Protein OGN; NGF; CSF1A; BTC; CTGF; CSF3; OSM; CNTF; BMP10; Il2
Function heparin binding
Related Protein APPB; CTGFA; SAA1; WISP1A; BMP4; RPL22; PTCH1; CXCL10; THBS2; FGFBP3
Function nucleotide binding
Related Protein RAB1BB; SRSF7B; VPS11; RAB18B; MAP4K6; STK35L; PRTFDC1; TDRD9; DDX19; ENOX2
Function poly(A) RNA binding
Related Protein DQX1; SART3; ANKRD17; FAM133B; CDKN2A; RPL26L1; MRPL10; RP9; POLR2B; CELF1
Function transcription corepressor binding
Related Protein FAM89B; NR1D1; SIX3; HDGF; RORA

Interacting Protein

HDGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HDGF.
DDX5; SRSF1; SSRP1; HDAC1; PARP1; PRKDC

HDGF Related Articles

Kang, S; Xiao, G; et al. Proteomics analysis of altered cellular metabolism induced by insufficient copper level. JOURNAL OF BIOTECHNOLOGY 189:15-26(2014).
Zhao, J; Ma, MZ; et al. Anti-HDGF Targets Cancer and Cancer Stromal Stem Cells Resistant to Chemotherapy. CLINICAL CANCER RESEARCH 19:3567-3576(2013).