Creative BioMart to Present at IMMUNOLOGY2024™|May 3-7, 2024|Booth #512 Learn More

HLA-C

Official Full Name

HLA-C major histocompatibility complex, class I, C [ Homo sapiens ]
Overview

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
Synonyms

major histocompatibility complex, class I, C; 4933; Ensembl:ENSG00000204525; FLJ27082; HLA class I histocompatibility antigen, Cw-1 alpha chain; MHC class I antigen heavy chain HLA-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; HLA class I histocompatibility antigen, C alpha chain; HLC-C; D6S204; PSORS1; HLA-JY3;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK293
In Vitro Cell Free System
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-C-4834H	Recombinant Human HLA-C Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-C-13811H	Recombinant Human HLA-C, GST-tagged	E.coli	GST	28-306a.a.	$319 / 25ug
Human	HLA-C-268H	Recombinant Human major histocompatibility complex, class I, C, His-tagged	E.coli	His		Inquiry
Human	HLA-C-5498HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HLA-C-2940H	Recombinant Human HLA-C Protein (Ser48-Thr305), His tagged	E.coli	His	Ser48-Thr305	Inquiry
Human	HLA-C-269H	Recombinant Human HLA-C protein, His-tagged	HEK293	His		Inquiry
Human	HLA-C-242H	Recombinant Human HLA-C Protein, His-tagged	E.coli	His	Ser48~Thr305	Inquiry
Human	HLA-C-3560HF	Recombinant Full Length Human HLA-C Protein, GST-tagged	In Vitro Cell Free System	GST	336 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

HLA-C involved in several pathways and played different roles in them. We selected most pathways HLA-C participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	HSP70L;ARPC1B;ASAP3;ERBB4A;PSD;WASH;CYTH4;RAB11FIP4;FAM21C
Phagosome	ITGA2;TAP1;DYNC1I2A;NCF2;TLR2-2;NOX1;MHC1UEA;PIKFYVE;THBS2
Cell adhesion molecules (CAMs)	HLA-DQA2;CLDNA;SDC2;CLDN23;CD8B1;MPZL1L;CLDN10A;SELP;CNTN1
Antigen processing and presentation	KIR2DS3;KLRD1;TAP2;KIR2DL1;HLA-DRB1;H2-AB1;CTSB;KLRC2;HLA-DRB3
Natural killer cell mediated cytotoxicity	SOS1;PIK3R3;IFNA14;MAP2K1;ICAM1;RAET1D;PPP3R2;NCR1;PPP3CB
Type I diabetes mellitus	HLA-DMB;HLA-DRB5;INS2;GAD2;Il2;GAD1;INS1;INS;HSPD1
HTLV-I infection	STAT5A;NRAS;CD3G;APC;PIK3CD;RRAS2;WNT3;SLC25A5;FZD6
Herpes simplex infection	H2-Q10;THOC4;POU2F3;NFKBIAA;STAT1B;PVRL1B;BLB2;IL6;SRSF5
Epstein-Barr virus infection	SFPI1;TBK1;POLR3C;PRKACG;TBPL2;CD44;TYK2;HSPA8;HLA-DPB1
Viral carcinogenesis	HLA-F;HIST1H2BM;STAT5B;HPN;MAPK1;YWHAB;HIST1H4B;ACTN1;H2-Q10
Autoi	HLA-DRB4;HLA-DPB1;IFNA12;HLA-E;Ifna11;CD40;IFNA8;HLA-G;HLA-DPA1
ne thyroid disease	IL4;TPO;IFNA13;IL5;FASLG;HLA-G;IFNA21;HLA-E;TSHR
Allograft rejection	PRF1;FASLG;HLA-G;IL4;H2-AB1;HLA-DRB4;GZMB;Fasl;HLA-DMA
Graft-versus-host disease	HLA-DRB1;HLA-DQA2;HLA-DMA;FASLG;Il2;HLA-F;Fasl;CD86;GZMB
Viral myocarditis	RAC2;ACTB;CAV1;SGCB;CD86;HLA-A;ITGB2;ITGB2L;HLA-DQB1

HLA-C has several biochemical functions, for example, TAP binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-C itself. We selected most functions HLA-C had, and list some proteins which have the same functions with HLA-C. You can find most of the proteins on our site.

Function	Related Protein
TAP binding	HLA-C;H2-Q10;HLA-B;HLA-A
peptide antigen binding	H2-Q10;H2-AA;HLA-DQA1;MHC1UJA;MHC1UXA2;BF2;MHC1UKA;HLA-DPA1;TUBB3

HLA-C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-C here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-C.

Gene Family

Research Area

MHC Class I

MHC Class II

Law, MG; Achhra, A; et al. Clinical and demographic factors associated with low viral load in early untreated HIV infection in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV MEDICINE 16:37-45(2015).

Mahil, SK; Capon, F; et al. Genetics of Psoriasis. DERMATOLOGIC CLINICS 33:1-+(2015).