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KDM5D

Official Full Name

lysine (K)-specific demethylase 5D
Overview

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants.
Synonyms

KDM5D; lysine (K)-specific demethylase 5D; HY, HYA, JARID1D, jumonji, AT rich interactive domain 1D , Jumonji, AT rich interactive domain 1D (RBP2 like) , SMCY, Smcy homolog, Y linked (mouse); lysine-specific demethylase 5D; KIAA0234; H-Y; Histocompatibility Y antigen; HY; HYA; JAD1D; Jumonji/ARID domain-containing protein 1D; protein SmcY; Smcy homolog, Y-linked; SMC homolog, Y chromosome; Smcy homolog, Y chromosome; histone demethylase JARID1D; selected mouse cDNA on Y, human homolog of; Jumonji, AT rich interactive domain 1D (RBP2-like); SMCY; JARID1D;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	KDM5D-8597M	Recombinant Mouse KDM5D Protein	Mammalian Cell	His	Inquiry
Mouse	KDM5D-4785M	Recombinant Mouse KDM5D Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	KDM5D-4785M-B	Recombinant Mouse KDM5D Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
KDM5D Related Articles

KDM5D involved in several pathways and played different roles in them. We selected most pathways KDM5D participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM5D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	KDM2A;VPS72;PADI2;MORF4L1;MSL2B;MSL3;ING3;JHDM1D;CARM1
Chromatin organization	KDM3B;SMARCD1;SUZ12A;SMARCC2;CAPNS2;ELP4;PADI2;EP400;PHF20B
HDMs demethylate histones	KDM5BB;KDM6AL;KDM5BA;KDM2A;ARID5B;KDM2AA;KDM2B;KDM4D;PHF8

KDM5D has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM5D itself. We selected most functions KDM5D had, and list some proteins which have the same functions with KDM5D. You can find most of the proteins on our site.

Function	Related Protein
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity	KDM5D;KDM5BB;JMJD1C;PHF2
C-19 gibberellin 2-beta-dioxygenase activity	JMJD1C;KDM5BB;KDM5D;PHF2
C-20 gibberellin 2-beta-dioxygenase activity	PHF2;KDM5BB;JMJD1C;KDM5D
DNA binding	DNTTIP1;PIN4;TMPOB;NKX2.7;PRDM9;HMBOX1;DLX5A;ONECUT1;ZMAT4
DNA-N1-methyladenine dioxygenase activity	KDM5BB;KDM5D;ALKBH2;JMJD1C;FTO;ALKBH3;PHF2
dioxygenase activity	ASPHD2;ADOB;PLOD1A;KDM5D;ALOX8;PTGS2;OGFOD3;TDO2B;HPDA
histone demethylase activity (H3-K4 specific)	KDM1A;KDM5C;KDM5B;C14orf169;KDM5D
hypophosphite dioxygenase activity	KDM5D;JMJD1C;PHF2;KDM5BB
metal ion binding	TSSK5;ZNF705B;ZDHHC20A;ZNF558;ZFP579;PDE10A;ADAM25;E4F1;ADSSL
oxidoreductase activity	CREG1;IYD;HIBADHA;RDH10A;DLDH;KDM1B;TDO2B;RSAD1;CYP2P9
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	KDM5B;KDM5A;ALKBH5;KDM5BA;KDM5BB;TYW5;PHF8;ALKBH8;EGLN2
procollagen-proline dioxygenase activity	KDM5D;KDM5BB;JMJD1C;PHF2
sulfonate dioxygenase activity	JMJD1C;KDM5BB;PHF2;KDM5D
zinc ion binding	ADAMTS20;NR6A1;CA3;RNF141;ZCCHC11;KMT2E;LMO7;TRAF5;CALB1

KDM5D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM5D here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM5D.

Kawase, T; Ord, ND; et al. Frequency and Intensity of Antibody Responses to Antigens Encoded by KDM5D (SMCY) and Other H-Y Genes After Allogeneic Hematopoietic Cell Transplantation. BLOOD 118:1721-1721(2011).