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MADD

Official Full Name

MAP-kinase activating death domain
Overview

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.
Synonyms

MADD; MAP-kinase activating death domain; MAP kinase-activating death domain protein; DENN; KIAA0358; RAB3GEP; Rab3 GDP/GTP exchange factor; insulinoma glucagonoma clone 20; differentially expressed in normal and neoplastic cells; IG20; FLJ35600; FLJ36300;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MADD-4566HCL	Recombinant Human MADD 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MADD-2409H	Recombinant Human MADD Protein, His-tagged	E.coli	N-His	Asn1388-Ser1647	Inquiry
Rat	MADD-3530R	Recombinant Rat MADD Protein	Mammalian Cell	His		Inquiry
Rat	MADD-3186R	Recombinant Rat MADD Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Madd-1755R	Recombinant Rat Madd Protein, His-tagged	E.coli	N-His	Arg1291-Ser1602	Inquiry
Rat	MADD-3186R-B	Recombinant Rat MADD Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

MADD involved in several pathways and played different roles in them. We selected most pathways MADD participated on our site, such as Aminoacyl-tRNA biosynthesis, Cytosolic tRNA aminoacylation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MADD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Aminoacyl-tRNA biosynthesis	PARS2;EPRS;HARS2;KARS;TARSL2;IARS2;LARS2;FARSA;GARS
Cytosolic tRNA aminoacylation	FARSB;AARS;DARS;EEF1E1;AIMP1;MADD;KARS;AIMP2
Gene Expression	KHSRP;SNAPC2;ZNF34;ZNF669;PIWIL4;NKX2;NR2E1;ZNF224;ZNF764
tRNA Aminoacylation	AARS;EEF1E1;DARS;MADD;AIMP1;AIMP2;WARS2;EARS2;FARS2

MADD has several biochemical functions, for example, ATP binding, interleukin-8 receptor binding, NOT isoleucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MADD itself. We selected most functions MADD had, and list some proteins which have the same functions with MADD. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	UBE2G1B;SYK;ABCB1;INO80;DDX11;KIF20A;RAD17;ACTC1B;GRK7
interleukin-8 receptor binding	IL-8;MADD;YARS
NOT isoleucine-tRNA ligase activity	MADD;YARS
poly(A) RNA binding	AGO3;HNRNPU;RPL36A;NLRP11;RARS2;NSUN2;LUC7L3;AATF;SRSF7
signal transducer activity	GHRHRA;PLCD3;OLFR151;GNG13;GNG2;CTNNB2;MALT1;HTR1AB;GAB1
tRNA binding	TRMT11;METTL1;FDXACB1;YARS;PSTK;TERT;IGHMBP2;EIF2A;CTU1
tyrosine-tRNA ligase activity	MADD;YARS;YARS2

MADD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MADD here. Most of them are supplied by our site. Hope this information will be useful for your research of MADD.

PTPRN; POT1; YWHAZ; acnA; VPS13D; RB1CC1; WNK1