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MAEL

Official Full Name

maelstrom homolog (Drosophila)
Overview

Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage.
Synonyms

MAEL; maelstrom homolog (Drosophila); AU019877; 4933405K18Rik; protein maelstrom homolog;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MAEL-4564HCL	Recombinant Human MAEL 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	MAEL-9434M	Recombinant Mouse MAEL Protein	Mammalian Cell	His	Inquiry
Mouse	MAEL-5293M	Recombinant Mouse MAEL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	MAEL-5293M-B	Recombinant Mouse MAEL Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	MAEL-2622R	Recombinant Rhesus monkey MAEL Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	MAEL-2442R	Recombinant Rhesus Macaque MAEL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	MAEL-2442R-B	Recombinant Rhesus Macaque MAEL Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MAEL Related Articles

MAEL involved in several pathways and played different roles in them. We selected most pathways MAEL participated on our site, such as Gene Expression, Gene Silencing by RNA, PIWI-interacting RNA (piRNA) biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAEL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	BRF1B;SSRP1A;ZNF43;DNAJC8;ZNF136;MED23;LSM6;LCMT2;CD2BP2
Gene Silencing by RNA	TDRD1;ASZ1;MYBL1;PIWIL4;TNRC6B;TSNAX;DPY19L2;AGO3B;EIF2C3
PIWI-interacting RNA (piRNA) biogenesis	FKBP6;PIWIL4;DDX4;PLD6;MYBL1;TDRD1;MAEL;ASZ1;HENMT1

MAEL has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAEL itself. We selected most functions MAEL had, and list some proteins which have the same functions with MAEL. You can find most of the proteins on our site.

Function	Related Protein
sequence-specific DNA binding	ZSCAN4;HLFA;GRHL2;PPARA;HOXB5B;ZFP423;NR2F5;SPDEF;SP1

MAEL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAEL here. Most of them are supplied by our site. Hope this information will be useful for your research of MAEL.

NUDC

Lim, SL; Tsend-Ayush, E; et al. Conservation and Expression of PIWI-Interacting RNA Pathway Genes in Male and Female Adult Gonad of Amniotes. BIOLOGY OF REPRODUCTION 89:-(2013).

Takebe, M; Onohara, Y; et al. Expression of MAEL in nuage and non-nuage compartments of rat spermatogenic cells and colocalization with DDX4, DDX25 and MIWI. HISTOCHEMISTRY AND CELL BIOLOGY 140:169-181(2013).