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MBD4

Official Full Name

methyl-CpG binding domain protein 4
Overview

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
Synonyms

MBD4; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; MED1; G/T mismatch glycosylase; G/U mismatch glycosylase; methyl-CpG-binding protein MBD4; 3,N(4)-ethenocytosine glycosylase; methyl-CpG-binding endonuclease 1; mismatch-speci;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MBD4-224H	Recombinant Human MBD4 protein, T7/His-tagged	E.coli	T7/His	Inquiry
Human	MBD4-403HCL	Recombinant Human MBD4 lysate	HEK293	N/A	Inquiry
Human	MBD4-333H	Recombinant Human MBD4 Protein, His-tagged	Insect Cells	His	Inquiry
Chicken	MBD4-6259C	Recombinant Chicken MBD4	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
MBD4 Related Articles
MBD4 Related Research Area

MBD4 involved in several pathways and played different roles in them. We selected most pathways MBD4 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Base excision repair	POLD3;MUTYH;LIG3;PCNA;XRCC1;MPG;HMGB1B;POLE3;UNG

MBD4 has several biochemical functions, for example, endodeoxyribonuclease activity, protein binding, pyrimidine-specific mismatch base pair DNA N-glycosylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MBD4 itself. We selected most functions MBD4 had, and list some proteins which have the same functions with MBD4. You can find most of the proteins on our site.

Function	Related Protein
endodeoxyribonuclease activity	DNASE1L3;MBD4;DNASE2A;MRE11A;ZRANB3;DNASE1;ERCC5;APLF;DNASE1L2
protein binding	COMMD1;MEP1A;URM1;CALB1;ACAA2;CAMTA2;FOXM1;POLR2A;FAM176B
pyrimidine-specific mismatch base pair DNA N-glycosylase activity	TDG.1;TDG;MBD4
satellite DNA binding	CENPB;MBD4;MLH3

MBD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD4.

FADD; SUV39H1; KDM1A; TRIM27; FAS; HTT; CSNK2B; CDCA2; Prkci; Cep78

Thabet, Y; Le Dantec, C; et al. Epigenetic dysregulation in salivary glands from patients with primary Sjogren's syndrome may be ascribed to infiltrating B cells. JOURNAL OF AUTOIMMUNITY 41:175-181(2013).

Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).

Base Excision Repair