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MEIS1

  • Official Full Name

    Meis homeobox 1

  • Overview

    Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE (three amino acid loop extension) family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
  • Synonyms

    MEIS1; Meis homeobox 1; homeobox protein Meis1; WUGSC:H_NH0444B04.1; leukemogenic homolog protein; Meis1, myeloid ecotropic viral integration site 1 homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MEIS1-29559TH Recombinant Human MEIS1 Wheat Germ N/A 90 amino acids
Human MEIS1-26868TH Recombinant Human MEIS1 protein, GST-tagged Wheat Germ GST
Human MEIS1-4373HCL Recombinant Human MEIS1 293 Cell Lysate HEK293 N/A
Human MEIS1-1244H Recombinant Human MEIS1 protein, His-tagged Yeast His 180-320aa
Human MEIS1-4532H Recombinant Human MEIS1 Protein (Asp200-Met334), N-His tagged E.coli N-His Asp200-Met334
Mouse MEIS1-9722M Recombinant Mouse MEIS1 Protein Mammalian Cell His
Mouse MEIS1-5470M Recombinant Mouse MEIS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MEIS1-5470M-B Recombinant Mouse MEIS1 Protein Pre-coupled Magnetic Beads HEK293
Chicken MEIS1-3886C Recombinant Chicken MEIS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MEIS1 Related Articles

MEIS1 involved in several pathways and played different roles in them. We selected most pathways MEIS1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MEIS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsTCF3;GRB2;MAPK12;ACVR2B;RAF1;MAPK1;MEIS1;BMP4;WNT1
Transcriptional misregulation in cancerCD40;H3F3C;MLL1;IGF1R;PAX3;NFKB1;H3F3B;MEN1;BCL2L1

MEIS1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MEIS1 itself. We selected most functions MEIS1 had, and list some proteins which have the same functions with MEIS1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingFOXJ1;CUX2;MYOG;HOXA10;EHF;ZFP639;SOX1;SIX1;MAFB
chromatin bindingBRD4;TP53;NSD1;SIX1;NFIA;ERCC6;BARX2;HDAC2;MEIOB
protein bindingC3;PPEF1;TALDO1;E2F4;CBFB;NCAPH2;ACTL6A;ITGAX;ANKRD1
protein heterodimerization activityHIST1H2B7;ADRA1B;Fzd4;TFDP3;HIST1H4J;HIST1H4F;UGT1A1;TWIST1;CHRNA5
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGATA5;ATF2;SRY;OLIG2;SOX10;CIR1;HIF1A;CEBPA;HNF4A
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSOX2;YBX1;PAX5;HMGA2;TFE3A;ATOH1;MEIS1;GATA3;ZIC3

MEIS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MEIS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MEIS1.

CREB1; TLX1; ETS1; Creb1; TRMT10B; q8d1q5_yerpe; fos_mouse_gene; PBX1

Crist, RC; Roth, JJ; et al. A Conserved Tissue-Specific Homeodomain-Less Isoform of MEIS1 Is Downregulated in Colorectal Cancer. PLOS ONE 6:-(2011).
Cvejic, A; Serbanovic-Canic, J; et al. The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 96:190-198(2011).
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