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MID1

Official Full Name

midline 1 (Opitz/BBB syndrome)
Overview

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the RING-B box-coiled coil (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined.
Synonyms

MID1; midline 1 (Opitz/BBB syndrome); midline-1; FXY; OS; RNF59; TRIM18; BBBG 1; BBBG1; Finger on X and Y mouse homolog of; GBBB 1; GBBB1; MID 1; Midin; Midline 1; Midline 1 ring finger; Midline 1 RING finger protein; Midline1; OGS 1; OGS1; OSX; Putative transcription factor XPRF; RING finger protein 59; RNF 59; TRI18; TRI18_HUMAN; TRIM 18; Tripartite motif containing protein 18; Tripartite motif protein TRIM18; Tripartite motif-containing protein 18; XPRF; Zinc finger X and Y; ZNFXY; OTTHUMP00000022896; OTTHUMP00000022898; OTTHUMP00000022899; OTTHUMP00000022900; OTTHUMP00000022901; OTTHUMP00000022902; tripartite;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MID1-30200TH	Recombinant Human MID1	Wheat Germ	N/A	100 amino acids	Inquiry
Human	MID1-4322HCL	Recombinant Human MID1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MID1-4321HCL	Recombinant Human MID1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MID1-5328H	Recombinant Human MID1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	MID1-9832M	Recombinant Mouse MID1 Protein	Mammalian Cell	His		Inquiry
Mouse	Mid1-7951M	Recombinant Mouse Mid1 protein, His & T7-tagged	E.coli	His/T7	Met1~Leu212 (Accession # O70583)	Inquiry
Mouse	MID1-5555M	Recombinant Mouse MID1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MID1-5555M-B	Recombinant Mouse MID1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Mid1-4069M	Recombinant Mouse Mid1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	MID1-3682R	Recombinant Rat MID1 Protein	Mammalian Cell	His		Inquiry
Rat	MID1-3338R	Recombinant Rat MID1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MID1-3338R-B	Recombinant Rat MID1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	MID1-5705C	Recombinant Chicken MID1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MID1 involved in several pathways and played different roles in them. We selected most pathways MID1 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MID1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ubiquitin mediated proteolysis	UBE2O;CBLB;CUL4A;RHOBTB1;UBE2NB;ANAPC2;CDH1-A;PIAS1;UBR5

MID1 has several biochemical functions, for example, identical protein binding, ligase activity, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MID1 itself. We selected most functions MID1 had, and list some proteins which have the same functions with MID1. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	KCNJ10;PTPRM;PKD2;GM5077;CD247;TPD52L1;NISCH;EED;LTBR
ligase activity	MKRN2;TRIM13;RTCB;TTLL11;UBE1Y1;MARCH2;C12orf51;MYLIPA;UBE2D1B
microtubule binding	SGIP1;FAM154A;UXT;RAB11A;TRIM54;MAPRE3;KIF6;KLC3;KIFC1
phosphoprotein binding	RRAGA;SNCA;YWHAB;DPYSL3;TRPV1;LRP11;URI1;CACNB2;APTX
protein binding	UHMK1;FOXP2;MRPL10;CBLL1;CD40;SLC26A3;ESYT2;DDX5;DHX32
protein heterodimerization activity	SLC51A;SYT14;INHA;CHRAC1;BDKRB2;PBX1;SMC1A;BNIP3L;SYCP2
protein homodimerization activity	FLNA;SPATA24;UGT1A6;ATPIF1B;G6PDX;PDE2A;CADM4;ATG7;ASMT
ubiquitin protein ligase binding	Fzd4;CUL1B;DIO2;HSPA1L;UBE2N;UBE2KB;PRKAR2B;AMBRA1;PRKAR1A
zinc ion binding	DHX58;UQCRC1;CRIP3;CCNB1IP1;TRIM35-35;SEC24D;ZNRD1;ADH8B;VPS8

MID1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MID1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MID1.

UBE2E2; UBE2D1; UBE2D3; UBE2E3