MSH2
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Official Full Name
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
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Overview
The MSH2 gene is one of at least 4 genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma,While germline MSH2 mutations are responsible for approximately 50% of inherited, non-polyposis colorectal carcinoma (HNPCC). MSH2 encodes a protein of 934 amino acids. -
Synonyms
MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); COCA1, mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1); DNA mismatch repair protein Msh2; HNPCC; HNPCC1; hMSH2; FCC1; COCA1; LCFS2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Pig
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293F
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
MSH2 involved in several pathways and played different roles in them. We selected most pathways MSH2 participated on our site, such as Mismatch repair, Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mismatch repair | RFC5;RPA4;MSH3;MSH6;RPA3;LIG1;RPA2;RPA1;POLD4 |
| Pathways in cancer | MAP2K1;TFG;WNT6;PPARG;TGFB1;CXCR4;FZD2;TGFBR1;LAMA4 |
| Colorectal cancer | CCND1;TGFB2;PIK3CD;APC2;BAX;TRP53;MAPK8;MAPK9;TP53 |
MSH2 has several biochemical functions, for example, contributes_to ADP binding, contributes_to ATP binding, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH2 itself. We selected most functions MSH2 had, and list some proteins which have the same functions with MSH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ADP binding | MSH6;MSH2;ATP5D |
| contributes_to ATP binding | SFRP5;ABCG8;MSH2;ATP1A2;ATP5D;MSH6;ATP1B1 |
| contributes_to ATPase activity | ATP5A1;ATP5F1;ATP5C1;ATP1B1;MSH2;ATP5E;ABCG8;PPP2R4;ATP5I |
| DNA binding | CHD9;LASS2;TOP3B;FOXC1B;VDR;ZFP827;ARID1AA;HIST1H2AO;ZNF276 |
| DNA-dependent ATPase activity | DHX36;RAD51D;XRCC3;RAD51L1;MSH2;MSH5;DDX11;RAD51B;CHD6 |
| contributes_to MutLalpha complex binding | MSH6;MSH2 |
| Y-form DNA binding | WRN;MSH2;MEN1;MSH3;RAD18 |
| centromeric DNA binding | KIF2C;ZW10;MLH3;MSH3;CENPB;CENPC1;MSH2 |
| contributes_to dinucleotide insertion or deletion binding | MSH2;MSH3 |
| contributes_to dinucleotide repeat insertion binding | MSH2;MSH3 |
| double-strand/single-strand DNA junction binding | MSH3;MSH2 |
| contributes_to double-stranded DNA binding | STRA13;MSH6;APITD1;MSH2 |
| enzyme binding | HIST1H2AI;PHB;TAL1;PLAUR;ZNHIT6;TTN;CCND1;PHKG1;NR5A1 |
| contributes_to four-way junction DNA binding | MSH6;XRCC3;MSH2;XRCC2;RAD51L3;RAD51C;RAD51L1;RAD51D;RAD51B |
| contributes_to guanine/thymine mispair binding | MSH2;MSH6 |
| guanine/thymine mispair binding | |
| heteroduplex DNA loop binding | MSH2;MSH3 |
| contributes_to magnesium ion binding | MSH6;MSH2 |
| contributes_to mismatched DNA binding | MSH6;MSH2;MSH3 |
| contributes_to oxidized purine DNA binding | MSH6;MSH2 |
| protein C-terminus binding | STIP1;FOXN3;MLLT4;KCNJ11;OPRL1;PABPC1;KCNK3;CITED1;AGO2 |
| protein binding | ATP4B;C4BP;THAP10;HSF2;HSPH1;GSK3B;CREBZF;FAP;MAGEA11 |
| contributes_to protein binding | CRY1A;MEF2A;INHA;INTS10;PAK1;TGFBR3;MLH1;CPSF3L;MSH2 |
| protein homodimerization activity | PRDM6;UGT1A7;OXCT1;CTBP1;GM5506;CEACAM5;TYMS;E2F8;RBM11 |
| protein kinase binding | LATS1;MAP2K3;ITGB1BP1;RAB8A;CNPPD1;GCSAM;LLGL1;EEF1A2;PLCG1 |
| contributes_to single guanine insertion binding | MSH2;MSH3;MSH6 |
| contributes_to single thymine insertion binding | MSH6;MSH2 |
| contributes_to single-stranded DNA binding | MLH1;MSH3;IGJ;POLR2D;MSH2;IGHM;PMS2 |
MSH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH2.
MSH6; SLX4; EXO1; E2F3; BRCA1
Research Area
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