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Mll1

Official Full Name

myeloid/lymphoid or mixed-lineage leukemia 1
Overview

Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL (ALL1) gene. MLL stands for Myeloid/Lymphoid, or Mixed-Lineage, Leukemia.
Synonyms

Mll1; myeloid/lymphoid or mixed-lineage leukemia 1; HRX; Mll; All1; ALL-1; Cxxc7; HTRX1; KMT2A; mKIAA4050; 6430520K01;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	MLL1-9881M	Recombinant Mouse MLL1 Protein	Mammalian Cell	His	Inquiry
Mouse	MLL1-5582M	Recombinant Mouse MLL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	MLL1-5582M-B	Recombinant Mouse MLL1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
	Kit-1977	MLL1 SAM-Screener Assay Kit		N/A	Inquiry
	Kit-1781	MLL1 Complex Chemiluminescent Assay Kit		N/A	Inquiry

Involved Pathway
Protein Function
Interacting Protein

Mll1 involved in several pathways and played different roles in them. We selected most pathways Mll1 participated on our site, such as Lysine degradation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with Mll1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Lysine degradation	SETD2;SUV420H2;BBOX1;WBP7;ALDH3A2A;ACAT1;SETD8A;CAMKMT;SETD7
Transcriptional misregulation in cancer	TP53;PER2;MLLT3;ZBTB16;PLAT;PLAU;RXRB;PML;CEBPE

Mll1 has several biochemical functions, for example, DNA binding, chromatin binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Mll1 itself. We selected most functions Mll1 had, and list some proteins which have the same functions with Mll1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFP280D;ZNF625;NR1H3;ZNF789;ZBTB43;RAD51B;PIF1;CAMTA1;STAT3
chromatin binding	HHEX;ERG;NR5A1B;CRTC2;EBF2;RUNX2;RBMX;DNAJC2;SOX10
core promoter sequence-specific DNA binding	PROX1;SOHLH1;H2AFY;NR1D1;CREM;KLF10;PDX1;NR1D2;CHD2
histone methyltransferase activity (H3-K4 specific)	WBP7;MLL1;SETD3;MLL5;ASH1L;WDR82;KMT2E;WHSC1L1;KMT2A
histone-lysine N-methyltransferase activity	SUV420H1;WHSC1L1;SMYD2A;SETDB1A;SETD8A;PRDM7;SETDB1;SMYD1;PRDM9
identical protein binding	TRIP13;ERBB3;DIAPH1;GM5077;NOD1;SP100;ALDOA;BTK;CDC42
lysine-acetylated histone binding	MLL1;TRIM24;PSME4;SMARCA4;BRD9;PSME4B;BRD7;TAF1L;BRDT
metal ion binding	ZFP36L1B;CYP39A1;CYP2AA6;TDP2B;ZNF485;ZFAND5A;MTHFS;ZNF500;PRICKLE1B
methyltransferase activity	C9orf114;METTL10;THUMPD3;PRMT3;SMYD2B;SMYD1B;C2orf56;CMTR2;PRMT10
protein binding	GATAD2B;FOXD3;KARS;TNFSF14;RPS27A;SCARA3;CCT5;FBXW11;CHRAC1
protein homodimerization activity	TERFA;FGFR1;SLC11A1;BCL2;ATIC;PITX2;GLA;DMRT2A;SMAD3
transcription regulatory region DNA binding	ZNF821;TFE3;SOX17;ARRB1;CALCOCO1;GFI1;BCL11B;TBL1X;NKX2-1
transferase activity	GSBP9;AANAT2;POLR3B;LTK;ZNF143B;NDUFAF6;EPHB2B;EXT1A;C1GALT1B
unmethylated CpG binding	DNMT3B;KDM2A;CXXC1;MLL1;DNMT3A
zinc ion binding	USP22;LONRF3;ERI2;L3MBTL4;PDLIM4;JADE3;P2RX1;AMFR;RNF6

Mll1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Mll1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Mll1.

siglecg_mouse_gene; Rbbp5