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NCKAP1L

Official Full Name

NCK-associated protein 1-like
Overview

This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.
Synonyms

NCKAP1L; NCK-associated protein 1-like; HEM1, hematopoietic protein 1; 4930568P13Rik; AI463083; HEM1; Hematopoietic protein 1; HEMATOPOIETIC PROTEIN HEM-1; Hemp1; Membrane associated protein hem1; Membrane-associated protein HEM-1; NCK associated protein 1 like; NCKPL_HUMAN;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NCKAP1L-13732H	Recombinant Human NCKAP1L, GST-tagged	E.coli	GST	453-613a.a.	$319 / 25ug
Chicken	NCKAP1L-2993C	Recombinant Chicken NCKAP1L	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NCKAP1L involved in several pathways and played different roles in them. We selected most pathways NCKAP1L participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCKAP1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Regulation of actin cytoskeleton	ABI2;PIK3R1;CHRM5B;PPP1CB;CFL2;ITGA6B;ITGAL;RHOAC;FGD

NCKAP1L has several biochemical functions, for example, GTPase activator activity, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCKAP1L itself. We selected most functions NCKAP1L had, and list some proteins which have the same functions with NCKAP1L. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	ARHGDIA;ASAP3;TBC1D10A;RABGAP1;ARHGAP9;CHN2;SOS1;ASAP2A;TBC1D19
protein binding	PDK3;KLHL12;RBM11;EIF3A;CDC20;LMX1A;NAA10;SNX8;MCM10
protein complex binding	BAX;THRA;TG;RNF40;TXN2;VHLL;GIT1;Ctsl;AP2A1
protein kinase activator activity	DUSP19;MT3;FAM58A;NKX3;TOM1L1;MARK2;CAB39;STRADA;NCKAP1L

NCKAP1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCKAP1L here. Most of them are supplied by our site. Hope this information will be useful for your research of NCKAP1L.

GAS7; 15-deoxy-delta(12,14