Creative BioMart to Present at IMMUNOLOGY2024™|May 3-7, 2024|Booth #512 Learn More

NFATC3

Official Full Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Overview

The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
Synonyms

NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; nuclear factor of activated T-cells, cytoplasmic 3; NFAT4; NFATX; NF-ATc3; T cell transcription factor NFAT4; nuclear factor of activated T-cells c3 isoform IE-Xa;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Wheat Germ

Tag

Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFATC3-27538TH	Recombinant Human NFATC3	Wheat Germ	N/A	1068 amino acids	Inquiry
Human	NFATC3-29252TH	Recombinant Human NFATC3	Wheat Germ	N/A	80 amino acids	Inquiry
Human	NFATC3-3856HCL	Recombinant Human NFATC3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NFATC3-339HF	Recombinant Full Length Human NFATC3 Protein	In Vitro Cell Free System		1068 amino acids	Inquiry
Human	NFATC3-236H	Recombinant Human NFATC3 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	NFATC3-5888H	Recombinant Human NFATC3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Nfatc3-4389M	Recombinant Mouse Nfatc3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

NFATC3 involved in several pathways and played different roles in them. We selected most pathways NFATC3 participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	CDC25B;CACNA2D4;FGF6B;STMN1;FGF13;NTF4;MAPKAPK2A;FGF6A;RPS6KA3B
cGMP-PKG signaling pathway	PPP3R1;BAD;KCNJ8;SLC25A31;NFATC1;NPPB;ATP2A1;PPP3CA;PIK3CA
Wnt signaling pathway	DKK2;TCF7L1A;FZD7;PORCNL;FZD8;PRICKLE1A;DKK4;LEF1;RHOAC
Axon guidance	ITGB3A;EPHA8;LRRC4;ROBO1;DLG4;LIMK2;RANBP9;KLB;RND1
T cell receptor signaling pathway	CD4;MAP2K1;CDC42;PIK3R2;BCL10;HRAS;PPP3CB;CD8B;MAPK12
B cell receptor signaling pathway	PIK3R5;NFATC3;CD79B;CD81;VAV1;PLEKHA2;DAPP1;PILRB;BCL2L11
Oxytocin signaling pathway	MAPK3;RCAN1;PRKAA2;HRAS;PRKAB1;PPP3CC;EEF2K;OXTR;ITPR1
Hepatitis B	STAT2;PRKCG;PIK3R1;PIK3CB;TGFBR1;DDX58;PIK3CD;FASLG;IRF3
HTLV-I infection	IL1R2;TERT;TP53;TLN1;WNT2B;PPP3CA;HLA-DPB1;EGR2;DVL3

NFATC3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC3 itself. We selected most functions NFATC3 had, and list some proteins which have the same functions with NFATC3. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NFATC2;KLF17;PYDC3;FOXJ2;NKX6-2;RFX4;CEBPE;FOXA2;RFX5
chromatin binding	SMARCD1;TCF7L1A;RCC1;GATA3;SMC3;NR5A1;ERCC6;GM606;MNT
protein binding	NSMCE1;RLTPR;CHN1;CLEC16A;F3;AICDA;TSKS;RPL27A;SYNGR1
transcription factor binding	APBB3;CCND1;VDRA;FOXF2;RARA;CRY1;ARNT;DIP2C;APBB1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	HLTF;DDIT3;CDX4;ELK1;CREB3L1;NR3C1;PLAG1;GABPA;FOXI1

NFATC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC3.

CDK6; RAF1

Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).

Dong, YP; Pan, QX; et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 446:85-90(2014).

Transcription Regulators in VSMC

T Cell Cytokine Signaling

C-type Lectin Receptors