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NSD1

  • Official Full Name

    nuclear receptor binding SET domain protein 1

  • Overview

    This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms

    NSD1; nuclear receptor binding SET domain protein 1; Sotos syndrome , STO; histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; ARA267; FLJ22263; KMT3B; H3-K36-HMTase; H4-K20-HMTase; lysine N-methyltransferase 3B; NR-binding SET dom;

  • Recombinant Proteins
  • Assay Kits
  • Human
  • E. coli
  • E.coli
  • Insect Cell
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NSD1-03H Active Recombinant Human NSD1 protein, GST-tagged E.coli GST 1852-2082aa
Human NSD1-82H Recombinant Human NSD1, GST-tagged E.coli GST
Human NSD1-143H Recombinant Human NSD1 Protein, His-tagged Insect Cell His 1538-2696
Human NSD1-035H Recombinant Human NSD1 Protein, GST-tagged E. coli GST 1700-1986
Human NSD1-002H Recombinant Human NSD1 Protein, GST-tagged E.coli GST 1700-1986
Human NSD1-2813H Recombinant Human NSD1 protein, His-tagged E.coli His 341-630 aa
Kit-1787 NSD1 Chemiluminescent Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NSD1 Related Articles

NSD1 involved in several pathways and played different roles in them. We selected most pathways NSD1 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lysine degradationSUV39H1;SUV420H2;OGDHA;SETDB2;ALDH9A1A.1;WBP7;GCDHA;MLL5;CAMKMT

NSD1 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, androgen receptor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NSD1 itself. We selected most functions NSD1 had, and list some proteins which have the same functions with NSD1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter sequence-specific DNA bindingHOXB3;ZNF277;SOX3;NSD1;MAZ;IRF7;PAX6;SMAD5;RUNX2
androgen receptor bindingPRKCB;RAN;PIAS2;TGFB1I1;NSD1;PKN1;DDX5;WIPI1;PARK7
chromatin bindingSUPT5H;SP140;CDCA5;PCGF2;EGFR;SMARCD3;CBX4;HMGXB4A;EYA3
estrogen receptor bindingCTNNB1;MED1;NRIP1;DDX5;CCDC62;TAF10;PPARG;DYX1C1;TMEM38A
histone methyltransferase activity (H3-K36 specific)SMYD2A;SMYD2B;SETD3;SETMAR;NSD1;SETD2;SMYD2;ASH1L
histone methyltransferase activity (H4-K20 specific)NSD1;SUV420H1;SUV420H2;WHSC1
retinoic acid receptor bindingPRMT2;SNW1;RXRA;PRAME;ACTN4;PRAMEF10;ASXL1;NSD1;HMGA1-RS1
retinoid X receptor bindingRARB;NR0B2;RARG;NSD1;VDR;NCOR1;PPARG;NCOA1;FUS
thyroid hormone receptor bindingGAS2L1;NSD1;MED13;FUS;HMGN3;NR0B2;MED16;GTF2B;MED24
transcription cofactor activityZNF865;MXD1;PTPN14;MED1;LDB1A;NFE2L1;NSD1;ZNF763;ELK4
transcription corepressor activityBRD7;KCNIP3;ZFPM1;FOXP3;THRB;NSD1;ATF5;HIF3A;NPAT
zinc ion bindingRARAA;MICALL2B;RNF212;CREBBP;ZCCHC10;LHX2A;FTR82;LIMD2;NR1H3

NSD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NSD1.

zntA; glgX

Cui, JJ; McTigue, M; et al. Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer. JOURNAL OF MEDICINAL CHEMISTRY 55:8091-8109(2012).
Rhee, JM; Iannaccone, PM; et al. Mapping mouse hemangioblast maturation from headfold stages. DEVELOPMENTAL BIOLOGY 365:1-13(2012).
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