NSDHL
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Official Full Name
NAD(P) dependent steroid dehydrogenase-like
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Overview
The protein encoded by this gene is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in this gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males. Alternatively spliced transcript variants with differing 5 UTR have been found for this gene. -
Synonyms
NSDHL; NAD(P) dependent steroid dehydrogenase-like; sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E; member 1; XAP104; H105e3 protein; NAD(P) dependent steroid dehydrogenase like; Protein H105e3; Short chain dehydrogenase/reductase family 31E member 1; Sterol 4 alpha carboxylate 3 dehydrogenase decarboxylating; OTTHUMP00000025902; OTTHUMP00000025903; short chain dehydrogenase/reductase family 31E, member 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Dictyostelium discoideum (Slime mold)
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
NSDHL involved in several pathways and played different roles in them. We selected most pathways NSDHL participated on our site, such as Steroid biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSDHL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Steroid biosynthesis | FDFT1;CELL;CYP2R1;CYP51;SOAT1;SQLE;CEL.1;SC5DL;HSD17B7 |
| Metabolic pathways | PFKP;PIP5K1AB;PYCR1B;PLA2G6;PHOSPHO2;AZIN2;MAN1B1;ACSL4;UCK1 |
NSDHL has several biochemical functions, for example, 3-beta-hydroxy-delta5-steroid dehydrogenase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NSDHL itself. We selected most functions NSDHL had, and list some proteins which have the same functions with NSDHL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-beta-hydroxy-delta5-steroid dehydrogenase activity | NSDHL;HSD3B7;HSD3B2;HSD3B4;HSD3B6;HSD3B1;SDR42E1;HSD3B5 |
| sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity |
NSDHL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSDHL here. Most of them are supplied by our site. Hope this information will be useful for your research of NSDHL.
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