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NSMCE2

Official Full Name

non-SMC element 2, MMS21 homolog (S. cerevisiae)
Overview

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
Synonyms

NSMCE2; non-SMC element 2, MMS21 homolog (S. cerevisiae); C8orf36, chromosome 8 open reading frame 36 , non SMC element 2 homolog (MMS21, S. cerevisiae); E3 SUMO-protein ligase NSE2; FLJ32440; MMS21; NSE2; C8orf36; hMMS21; hNSE2; methyl methanesulfonate sensitivity gene 21; MMS21 homolog; non-SMC element 2; Non-SMC element 2 homolog; Non-structural maintenance of chromosomes element 2 homolog; NSE2_HUMAN;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NSMCE2-1375H	Recombinant Human NSMCE2, GST-tagged	E.coli	GST	1-247aa	$319 / 25ug
Human	NSMCE2-3685HCL	Recombinant Human NSMCE2 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	NSMCE2-10916M	Recombinant Mouse NSMCE2 Protein	Mammalian Cell	His		Inquiry
Mouse	NSMCE2-6223M-B	Recombinant Mouse NSMCE2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	NSMCE2-6223M	Recombinant Mouse NSMCE2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NSMCE2-4095R	Recombinant Rat NSMCE2 Protein	Mammalian Cell	His		Inquiry
Rat	NSMCE2-3756R	Recombinant Rat NSMCE2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NSMCE2-3756R-B	Recombinant Rat NSMCE2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	NSMCE2-4861C	Recombinant Chicken NSMCE2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NSMCE2 Related Articles

NSMCE2 involved in several pathways and played different roles in them. We selected most pathways NSMCE2 participated on our site, such as Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSMCE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism of proteins	GALNTL2;RING1;C8orf84;DAD1;MLEC;DPAGT1;TRAPPC4;ANKRD28;ARSD
Post-translational protein modification	ADAMTSL5;CBX4;TRAPPC6A;MUCL1;NSMCE2;MLEC;EIF5A;MGAT4B;GALNTL2
SUMO E3 ligases SUMOylate target proteins	CBX8;SCMH1;SMC6;SMC5;PHC2;PHC3;NSMCE1;NSMCE2;NSMCE4A
SUMOylation	RNF2;NSMCE1;UBA2;NSMCE4A;EID3;PHC1;SENP5;SENP1;CBX8
SUMOylation of DNA damage response and repair proteins	SCMH1;NSMCE2;CBX8;RNF2;NSMCE1;SMC5;EID3;PHC3;NSMCE4A

NSMCE2 has several biochemical functions, for example, SUMO transferase activity, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NSMCE2 itself. We selected most functions NSMCE2 had, and list some proteins which have the same functions with NSMCE2. You can find most of the proteins on our site.

Function	Related Protein
SUMO transferase activity	SUMO1;PIAS4;CBX4;NSMCE2;UBE2IB;PIAS3;SUMO4;TOPORS;UBE2I
ligase activity	LTN1;RNF144A;RNF125;RAD18;RNF40;RNF43;TRIM21;XIAP;NSMCE1
protein binding	FAM86A;PHLDA1;LOC149950;MED6;PBLD;CCND2;REXO1L1;TOP1;USO1
zinc ion binding	NR6A1;TRIM14;ADAM30;RBM5;ZRANB1B;ADAM17;ADH1;ADAMDEC1;CA5A

NSMCE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSMCE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NSMCE2.

SMC6; TXLNA; Smc6; NDNL2; SYNCRIP; Lck; ILK; Tgfbr1; SAMD1; NSMCE1; TM9SF4; SORT1; NIPSNAP1; Rbm8a

Dryden, NH; Broome, LR; et al. Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C. GENOME RESEARCH 24:1854-1868(2014).

Chinen, Y; Sakamoto, N; et al. 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia. JOURNAL OF HEMATOLOGY & ONCOLOGY 7:-(2014).