nxf1
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  • Official Full Name
  • nuclear RNA export factor 1
  • Background
  • This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • NXF1; nuclear RNA export factor 1; DKFZp667O0311; Mex67; TAP; tip associating protein; mRNA export factor TAP; tip-associated protein; tip-associating protein
Cat.#:NXF1-1427HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NXF1, GST-tagged
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Cat.#:NXF1-11014MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NXF1 Protein
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Cat.#:NXF1-4135RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NXF1 Protein
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Cat.#:NXF1-3622HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NXF1 293 Cell Lysate
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